UBOX5 - U-box domain containing 5 Gene

Also Known as UIP5; RNF37; hUIP5; UBCE7IP5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22888

About UBOX5

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,107,573-3,159,865 (from NCBI)

This gene has 3 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in testis (RPKM 3.8), ovary (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 Enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

UBOX5 Products (3)

mRNA	Protein	Name
NM_001267584.2	NP_001254513.1	RING finger protein 37 isoform c
NM_014948.4	NP_055763.1	RING finger protein 37 isoform a
NM_199415.3	NP_955447.1	RING finger protein 37 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11274149	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nuclear body	IDA IDA: Inferred from direct assay	11274149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBOX5 Protein Structure

U-box

0
100
200
300
400
500
541 a.a.

Protein Preferred Names	Protein Names
RING finger protein 37	RING-type E3 ubiquitin transferase RNF37

UBOX5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	UBOX5	O94941	VCP	Homo sapiens	P55072	Validated Y2H	32296183
Intra	UBOX5	O94941	VCP	Homo sapiens	P55072	Y2H Array	25416956
Intra	UBOX5	O94941	VCP	Homo sapiens	P55072	Y2H Array	32296183
Intra	UBOX5	O94941	VCP	Homo sapiens	P55072	Y2H Prey Pooling	32296183
Intra	UBOX5	O94941	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	UBOX5	O94941	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	UBOX5	O94941	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	UBOX5	O94941	MLH1	Homo sapiens	P40692	Y2H Array	31515488
Intra	UBOX5	O94941	MLH1	Homo sapiens	P40692	Validated Y2H	32296183
Intra	UBOX5	O94941	MLH1	Homo sapiens	P40692	Y2H Array	32296183
Intra	UBOX5	O94941	MLH1	Homo sapiens	P40692	Y2H Array	29892012
Intra	UBOX5	O94941	MLH1	Homo sapiens	P40692	Y2H Prey Pooling	32296183
Intra	UBOX5	O94941	MLH1	Homo sapiens	P40692	Y2H Pooling	27229929
Intra	UBOX5	O94941	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	UBOX5	O94941	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	UBOX5	O94941	ATXN1	Homo sapiens	P54253	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diabetes Insipidus, Neurohypophyseal	Neurohypophyseal Diabetes Insipidus Cdi Pituitary Diabetes Insipidus Vasopressin Defective Diabetes Insipidus Vasopressin Deficiency Central Diabetes Insipidus Diabetes Insipidus, Neurogenic Diabetes Insipidus, Primary Central Diabetes Insipidus, Cranial Type Diabetes Insipidus Secondary To Vasopressin Deficiency Diabetes Insipidus, Central Diabetes Insipidus, Pituitary NDI Diabetes Insipidus Cranial Type Neurogenic Diabetes Insipidus Primary Central Diabetes Insipidus
Mitochondrial Dna Depletion Syndrome 13	MTDPS13 Fbxl4 Deficiency Fbxl4-Related Encephalomyopathic Mitochondrial Dna Depletion Syndrome Mitochondrial Dna Depletion Syndrome 13, Encephalomyopathic Type Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies Mtdna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies Fbxl4-Related Early-Onset Mitochondrial Encephalopathy Mitochondrial Dna Depletion Syndrome 13 , Encephalomyopathic Type Bxl4-Related Early-Onset Mitochondrial Encephalopathy Encephalomyopathic Mitochondrial Dna Depletion Syndrome-13 Fbxl4-Related Early Onset Mitochondrial Encephalopathy Mitochondrial Dna Depletion Syndrome, Type 13

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15381	UBOX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UBOX5	VGNC	VGNC:66780
Macaca mulatta	UBOX5	VGNC	VGNC:98473
Canis familiaris	UBOX5	VGNC	VGNC:48083
Bos taurus	UBOX5	VGNC	VGNC:36612
Rattus norvegicus	UBOX5	RGD	RGD:1305440
Mus musculus	UBOX5	MGD	MGI:2154658
Others	UBOX5	NCBI