METTL17 - methyltransferase like 17 Gene

Also Known as METT11D1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64745

About METTL17

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,989,980-20,997,035 (from NCBI)

This gene has 25 transcripts (splice variants), 180 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 22.3), lymph node (RPKM 19.6) and 25 other tissues.

Summary

Predicted to enable S-adenosyl-L-methionine binding activity and mitochondrial ribosome binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

METTL17 Products (2)

mRNA Protein Name
NM_001029991.2 NP_001025162.1 methyltransferase-like protein 17, mitochondrial isoform 1 precursor
NM_022734.3 NP_073571.1 methyltransferase-like protein 17, mitochondrial isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 4 iron, 4 sulfur cluster binding IDA
IDA: Inferred from direct assay
36482135 GOA
NOT enables methyltransferase activity IDA
IDA: Inferred from direct assay
38234605 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial small ribosomal subunit assembly IDA
IDA: Inferred from direct assay
36482135 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL17 Protein Structure

Rsm22

Rsm22: Mitochondrial small ribosomal subunit Rsm22 (155 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

methyltransferase-like protein 17, mitochondrial

  • false p73 target gene protein

METTL17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
METTL17 Q9H7H0 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
METTL17 Q9H7H0 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
26871637
Intra
METTL17 Q9H7H0 MID2 Homo sapiens Q9UJV3-2
Y2H Array
26871637
Intra
METTL17 Q9H7H0 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
26871637
Intra
METTL17 Q9H7H0 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra
METTL17 Q9H7H0 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
METTL17 Q9H7H0 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
26871637
Intra
METTL17 Q9H7H0 PNMA1 Homo sapiens Q8ND90
Validated Y2H
26871637
Intra
METTL17 Q9H7H0 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra
METTL17 Q9H7H0 PNMA1 Homo sapiens Q8ND90
Y2H Array
26871637
Intra
METTL17 Q9H7H0 SF3B4 Homo sapiens Q15427
Y2H Array
25416956
Intra
METTL17 Q9H7H0 TRAF1 Homo sapiens Q13077
Validated Y2H
26871637
Intra
METTL17 Q9H7H0 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
26871637
Intra
METTL17 Q9H7H0 TRAF1 Homo sapiens Q13077
Y2H Array
26871637
Intra
METTL17 Q9H7H0 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra
METTL17 Q9H7H0 MDFI Homo sapiens Q99750
Y2H Prey Pooling
26871637
Intra
METTL17 Q9H7H0 MDFI Homo sapiens Q99750
Validated Y2H
26871637
Intra
METTL17 Q9H7H0 MDFI Homo sapiens Q99750
Y2H Array
26871637
Intra
METTL17 Q9H7H0 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
METTL17 Q9H7H0 CALCOCO2 Homo sapiens Q13137
Validated Y2H
26871637
Intra
METTL17 Q9H7H0 CALCOCO2 Homo sapiens Q13137
Y2H Array
26871637
Intra
METTL17 Q9H7H0 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra
METTL17 Q9H7H0 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
26871637
Intra
METTL17 Q9H7H0 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
26871637
Intra
METTL17 Q9H7H0 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
26871637
Intra
METTL17 Q9H7H0 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra
METTL17 Q9H7H0 CEP70 Homo sapiens Q8NHQ1
Y2H Array
26871637
Intra
METTL17 Q9H7H0 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
Intra
METTL17 Q9H7H0 CBY2 Homo sapiens Q8NA61
Validated Y2H
25416956
Intra
METTL17 Q9H7H0 ATXN1 Homo sapiens P54253
Y2H Array
16713569
Intra
METTL17 Q9H7H0 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08358 METTL17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus METTL17 MGD MGI:1098577
Canis familiaris METTL17 VGNC VGNC:106604
Macaca mulatta METTL17 VGNC VGNC:81473
Felis catus METTL17 VGNC VGNC:80913
Bos taurus METTL17 VGNC VGNC:55124
Rattus norvegicus METTL17 RGD RGD:1559895
Others METTL17 NCBI