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MAGEC2 - MAGE family member C2 Gene

Also Known as CT10; HCA587; MAGEE1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51438

About MAGEC2

Cytogenetic location: Xq27.2 Genomic coordinates (GRCh38): X:142,202,342-142,205,290 (from NCBI)

This gene has 1 transcript (splice variant), 463 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 15.6).

Summary

This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the Other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]

MAGEC2 Products (1)

mRNA	Protein	Name
NM_016249.4	NP_057333.1	melanoma-associated antigen C2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20864041	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	20864041	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	20864041	GOA
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	20864041	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEC2 Protein Structure

MAGE_N

MAGE

0
100
200
300
373 a.a.

Protein Preferred Names	Protein Names
melanoma-associated antigen C2	MAGE-C2 antigen

MAGEC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAGEC2	Q9UBF1	P4HA3	Homo sapiens	Q7Z4N8	Validated Y2H	25416956
Intra	MAGEC2	Q9UBF1	P4HA3	Homo sapiens	Q7Z4N8	Y2H Array	31515488
Intra	MAGEC2	Q9UBF1	SSX1	Homo sapiens	Q16384	Y2H Prey Pooling	25416956
Intra	MAGEC2	Q9UBF1	SSX1	Homo sapiens	Q16384	Y2H Array	25416956
Intra	MAGEC2	Q9UBF1	PBX3	Homo sapiens	Q5JS98	Y2H Prey Pooling	25416956
Intra	MAGEC2	Q9UBF1	PBX3	Homo sapiens	Q5JS98	Validated Y2H	25416956
Intra	MAGEC2	Q9UBF1	PBX3	Homo sapiens	Q5JS98	Y2H Array	25416956
Intra	MAGEC2	Q9UBF1	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	MAGEC2	Q9UBF1	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	MAGEC2	Q9UBF1	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	MAGEC2	Q9UBF1	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	MAGEC2	Q9UBF1	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	MAGEC2	Q9UBF1	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	MAGEC2	Q9UBF1	UBE2H	Homo sapiens	P62256	Pull Down	20864041
Intra	MAGEC2	Q9UBF1	SSX2	Homo sapiens	Q16385	Y2H Array	25416956
Intra	MAGEC2	Q9UBF1	SSX2	Homo sapiens	Q16385	Y2H Prey Pooling	25416956
Intra	MAGEC2	Q9UBF1	SSX2	Homo sapiens	Q16385	Validated Y2H	25416956
Intra	MAGEC2	Q9UBF1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MAGEC2	Q9UBF1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	MAGEC2	Q9UBF1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MAGEC2	Q9UBF1	TRIM28	Homo sapiens	Q13263	Pull Down	20864041
Intra	MAGEC2	Q9UBF1	TRIM28	Homo sapiens	Q13263	Y2H	21277283
Intra	MAGEC2	Q9UBF1	TRIM28	Homo sapiens	Q13263	TAP	20864041

Cross: Cross-species interaction Intra: Intraspecies interaction

MAGEC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81369	MAGEC2 Antibody (YA1114)	IHC-P	Human
HY-P81369A	MAGEC2 Antibody (YA1114)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Malignant Anus Melanoma	Anal Melanoma Malignant Melanoma Of Anus
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07974	MAGEC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990834	Anti-MAGEC2/CT10 Antibody (LX-CT10.5)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAGEC2	RGD	RGD:1563272
Mus musculus	MAGEC2	MGD	MGI:1921687
Others	MAGEC2	NCBI