SSX1 - SSX family member 1 Gene

Also Known as SSRC; CT5.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6756

About SSX1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,255,392-48,267,444 (from NCBI)

This gene has 1 transcript (splice variant), 105 orthologues, 7 paralogues and is associated with 70 phenotypes. Restricted expression toward testis (RPKM 3.9).

Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]

SSX1 Products (2)

mRNA	Protein	Name
NM_001278691.2	NP_001265620.1	protein SSX1
NM_005635.4	NP_005626.1	protein SSX1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	10072425	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10072425	GOA
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	36796361	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10072425	GOA
located in sperm flagellum	IMP IMP: Inferred from mutant phenotype	36796361	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSX1 Protein Structure

SSXRD

0
100
188 a.a.

Protein Preferred Names	Protein Names
protein SSX1	cancer/testis antigen 5.1

SSX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SSX1	Q16384	MTURN	Homo sapiens	Q8N3F0	Validated Y2H	32296183
Intra	SSX1	Q16384	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	32296183
Intra	SSX1	Q16384	MAGEC2	Homo sapiens	Q9UBF1	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Biphasic Synovial Sarcoma	Synovial Sarcoma, Biphasic Biphasic Sarcoma Of Synovium
Spindle Cell Synovial Sarcoma	Synovial Sarcoma With Spindle Cell Components Synovial Sarcoma, Monophasic Fibrous Synovial Sarcoma, Spindle Cell
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Monophasic Synovial Sarcoma	Monophasic Sarcoma Of Synovium
Tibial Adamantinoma	Tibial Adamantinoma Morphology
Adamantinoma Of Long Bones	Long Bone Adamantinoma
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Lung Sarcoma	Pulmonary Sarcoma
Spermatic Cord Cancer	Malignant Tumor Of Spermatic Cord Malignant Tumor Of The Spermatic Cord Spermatic Cord Ca Malignant Neoplasm Of Spermatic Cord
Extraskeletal Mesenchymal Chondrosarcoma	Mesenchymal Extraosseous Chondrosarcoma
Synovium Neoplasm	Synovial Neoplasm Tumor Of Synovium
Adult Cystic Nephroma	Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour And Renal Epithelial Stromal Tumour
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Cellular Schwannoma	Cellular Neurinoma
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Heart Sarcoma	Cardiac Sarcoma Sarcoma Of Heart
Bone Angioendothelial Sarcoma	Osseous Hemangiosarcoma Bone Angiosarcoma
Mediastinal Mesenchymal Tumor	Mediastinal Mesenchymal Tumour Soft Tissue Tumor Of Mediastinum Soft Tissue Tumour Of Mediastinum
Cellular Myxoid Liposarcoma	Round Cell Liposarcoma
Extraosseous Osteosarcoma	Extraskeletal Osteosarcoma Extraskeletal Osteogenic Sarcoma
Hemangiopericytoma, Malignant	Hemangiopericytoma Haemangiopericytic Meningioma Malignant Hemangiopericytoma Solitary Fibrous Tumor
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Juxtacortical Chondroma	Periosteal Chondroma
Pleomorphic Liposarcoma	Pls Liposarcoma Pleomorphic Liposarcoma, Pleomorphic
Kidney Sarcoma	Renal Sarcoma Sarcoma Of Kidney
Extraosseous Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Sarcomatoid Mesothelioma	Malignant Fibrous Mesothelioma Spindled Mesothelioma
Alveolar Soft Part Sarcoma	ASPS Alveolar Soft-Part Sarcoma Sarcoma, Alveolar Soft Part Alveolar Soft Tissue Sarcoma Sarcoma Alveolar Soft Part Adult Alveolar Soft-Part Sarcoma Childhood Alveolar Soft-Part Sarcoma
Kidney Fibrosarcoma	Fibrosarcoma Of The Kidney
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Rhabdomyosarcoma
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Desmoplastic Small Round Cell Tumor	Dsrct Desmoplastic Small Round-Cell Tumor Desmoplastic Small Round-Cell Neoplasm
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Kidney Clear Cell Sarcoma	Clear Cell Sarcoma Of Kidney Childhood Kidney Clear Cell Sarcoma Renal Clear Cell Sarcoma Ccsk Clear Cell Sarcoma Of The Kidney
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148739	dBRD 9-A		99.50%	Unkown
HY-RS13836	SSX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown