LHX8 - LIM homeobox 8 Gene

Also Known as LHX7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 431707

About LHX8

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:75,128,434-75,199,454 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 20 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

LHX8 Products (2)

mRNA	Protein	Name
NM_001001933.1	NP_001001933.1	LIM/homeobox protein Lhx8 isoform 1
NM_001256114.2	NP_001243043.1	LIM/homeobox protein Lhx8 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHX8 Protein Structure

LIM

Homeobox

0
100
200
300
356 a.a.

Protein Preferred Names	Protein Names
LIM/homeobox protein Lhx8	LIM-homeodomain protein Lhx8

LHX8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LHX8	Q68G74	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	LHX8	Q68G74	NUTM1	Homo sapiens	Q86Y26	Y2H Prey Pooling	25416956
Intra	LHX8	Q68G74	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	LHX8	Q68G74	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	LHX8	Q68G74	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	LHX8	Q68G74	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	LHX8	Q68G74	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	LHX8	Q68G74	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	LHX8	Q68G74	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	LHX8	Q68G74	FOXN1	Homo sapiens	O15353	Y2H Array	32296183
Intra	LHX8	Q68G74	FOXN1	Homo sapiens	O15353	Y2H Prey Pooling	32296183
Intra	LHX8	Q68G74	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	LHX8	Q68G74	EFS	Homo sapiens	O43281-2	Y2H Array	32296183
Intra	LHX8	Q68G74	EFS	Homo sapiens	O43281-2	Y2H Prey Pooling	32296183
Intra	LHX8	Q68G74	FIGLA	Homo sapiens	Q6QHK4	Validated Y2H	32296183
Intra	LHX8	Q68G74	FIGLA	Homo sapiens	Q6QHK4	Complementation	32296183
Intra	LHX8	Q68G74	LDB1	Homo sapiens	Q86U70-2	Validated Y2H	32296183
Intra	LHX8	Q68G74	LDB1	Homo sapiens	Q86U70-2	Y2H Array	32296183
Intra	LHX8	Q68G74	LDB1	Homo sapiens	Q86U70-2	Y2H Prey Pooling	32296183
Intra	LHX8	Q68G74	ATF6B	Homo sapiens	Q96QL7	Y2H Prey Pooling	32296183
Intra	LHX8	Q68G74	ATF6B	Homo sapiens	Q96QL7	Validated Y2H	32296183
Intra	LHX8	Q68G74	ATF6B	Homo sapiens	Q96QL7	Y2H Array	32296183
Intra	LHX8	Q68G74	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32814053
Intra	LHX8	Q68G74	TSC1	Homo sapiens	Q86WV8	Y2H Array	32814053
Intra	LHX8	Q68G74	TSC1	Homo sapiens	Q86WV8	Y2H Pooling	32814053
Intra	LHX8	Q68G74	SCYL3	Homo sapiens	Q8IZE3	Y2H Prey Pooling	25416956
Intra	LHX8	Q68G74	SCYL3	Homo sapiens	Q8IZE3	Validated Y2H	25416956
Intra	LHX8	Q68G74	SCYL3	Homo sapiens	Q8IZE3	Y2H Array	25416956
Intra	LHX8	Q68G74	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	32296183
Intra	LHX8	Q68G74	TBC1D1	Homo sapiens	Q86TI0	Y2H Prey Pooling	32296183
Intra	LHX8	Q68G74	TBC1D1	Homo sapiens	Q86TI0	Y2H Array	32296183
Intra	LHX8	Q68G74	TBC1D1	Homo sapiens	Q86TI0	Validated Y2H	32296183
Intra	LHX8	Q68G74	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	LHX8	Q68G74	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	LHX8	Q68G74	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	LHX8	Q68G74	LDB2	Homo sapiens	O43679	Y2H Prey Pooling	32296183
Intra	LHX8	Q68G74	LDB2	Homo sapiens	O43679	Y2H Array	32296183
Intra	LHX8	Q68G74	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	LHX8	Q68G74	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	LHX8	Q68G74	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	LHX8	Q68G74	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	LHX8	Q68G74	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	LHX8	Q68G74	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	LHX8	Q68G74	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	LHX8	Q68G74	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	LHX8	Q68G74	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	LHX8	Q68G74	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	LHX8	Q68G74	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	LHX8	Q68G74	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	LHX8	Q68G74	LDB1	Homo sapiens	Q86U70	Y2H Array	25416956
Intra	LHX8	Q68G74	LDB1	Homo sapiens	Q86U70	BioID	35140242
Intra	LHX8	Q68G74	LDB1	Homo sapiens	Q86U70	Affinity Chrom	35140242
Intra	LHX8	Q68G74	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	LHX8	Q68G74	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	LHX8	Q68G74	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	LHX8	Q68G74	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	LHX8	Q68G74	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	LHX8	Q68G74	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	LHX8	Q68G74	GINS4	Homo sapiens	Q9BRT9	Validated Y2H	32296183
Intra	LHX8	Q68G74	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	LHX8	Q68G74	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	LHX8	Q68G74	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	LHX8	Q68G74	KLF3	Homo sapiens	P57682	Validated Y2H	25416956
Intra	LHX8	Q68G74	KLF3	Homo sapiens	P57682	Y2H Array	25416956
Intra	LHX8	Q68G74	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183
Intra	LHX8	Q68G74	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	LHX8	Q68G74	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	LHX8	Q68G74	PEX1	Homo sapiens	O43933	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Odontoma
Neuropathy, Hereditary Sensory And Autonomic, Type Iia	Hereditary Sensory And Autonomic Neuropathy Type 2 Hsan2 HSAN2A Morvan Disease Hereditary Sensory And Autonomic Neuropathy Type Ii Neurogenic Acroosteolysis Hsan Iia Hsn2a Hsn Iia Neuropathy, Progressive Sensory, Of Children Neuropathy, Congenital Sensory Neuropathy, Hereditary Sensory And Autonomic, Type Ii Hereditary Sensory And Autonomic Neuropathy Type 2a Hereditary Sensory And Autonomic Neuropathy Type Iia Hsanii Congenital Sensory Neuropathy Hsan Type Ii Morvan Syndrome Neuropathy, Hereditary Sensory And Autonomic, Type 2a Morvan'S Disease Neuropathy, Hereditary Sensory, Type Iia Acroosteolysis, Neurogenic Acroosteolysis, Giaccai Type Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive Hereditary Sensory Autonomic Neuropathy Type 2 Giaccai Type Acroosteolysis Hereditary Sensory Neuropathy Type 2 Hereditary Sensory Radicular Neuropathy, Recessive Form Hsan2b Hsan2c Hsan2d Hsn Type Ii Autosomal Recessive Sensory Radicular Neuropathy Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome Morvan Fibrillary Chorea Neuropathy, Hereditary Sensory And Autonomic, 2a Acroosteolysis Giaccai Type Hereditary Sensory Neuropathy Type Iia Hereditary Sensory Radicular Neuropathy Autosomal Recessive Progressive Sensory Neuropathy Of Children Neuropathy Congenital Sensory Charcot-Marie-Tooth Disease Neuropathy, Sensory And Autonomic, Hereditary, Type Iia Hereditary Sensory Autonomic Neuropathy, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii Sensory Neuropathy, Hereditary Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Geotrichosis
Cerebral Hemisphere Lipoma	Lipoma Of The Cerebral Hemisphere
Corpus Callosum Lipoma	Lipoma Of The Corpus Callosum Lipoma Of Corpus Callosum
Cleft Lip	Cheiloschisis Labium Leporinum Cleft Lip, Unilateral, Complete Complete Unilateral Cleft Lip Hare Lip Congenital Fissure Of Lip Isolated Cleft Lip Cleft Lip Without Cleft Palate Cleft Lip Without Cleft Palate, Unilateral Isolated Cleft Lip, Unilateral Cleft Lip Without Cleft Palate, Bilateral Isolated Cleft Lip, Bilateral
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Central Nervous System Lipoma	Lipoma Of The Cns
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Van Der Woude Syndrome	Lip-Pit Syndrome Vws Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip Vdws Lps Lip Pit Syndrome Cleft Lip/Palate With Mucous Cysts Of Lower Lip Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments
Orofacial Cleft	Cleft, Orofacial
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07637	LHX8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LHX8	MGD	MGI:1096343
Canis familiaris	LHX8	VGNC	VGNC:42668
Rattus norvegicus	LHX8	RGD	RGD:1308749
Bos taurus	LHX8	VGNC	VGNC:30877
Felis catus	LHX8	VGNC	VGNC:63225
Macaca mulatta	LHX8	VGNC	VGNC:74144
Others	LHX8	NCBI