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GINS4 - GINS complex subunit 4 Gene

Also Known as SLD5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84296

About GINS4

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,529,261-41,545,030 (from NCBI)

This gene has 9 transcripts (splice variants) and 202 orthologues. Broad expression in lymph node (RPKM 2.4), appendix (RPKM 2.0) and 23 other tissues.

Summary

The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

GINS4 Products (1)

mRNA	Protein	Name
NM_032336.3	NP_115712.1	DNA replication complex GINS protein SLD5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	22474384	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CMG complex	IPI IPI: Inferred from physical interaction	22474384	GOA
part of GINS complex	IPI IPI: Inferred from physical interaction	17417653	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22474384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GINS4 Protein Structure

Sld5

0
100
200
223 a.a.

Protein Preferred Names	Protein Names
DNA replication complex GINS protein SLD5	SLD5 homolog

GINS4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GINS4	Q9BRT9	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	GINS4	Q9BRT9	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	GINS4	Q9BRT9	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	GINS4	Q9BRT9	KIF16B	Homo sapiens	Q96L93-6	Y2H Prey Pooling	32296183
Intra	GINS4	Q9BRT9	KIF16B	Homo sapiens	Q96L93-6	Y2H Array	32296183
Intra	GINS4	Q9BRT9	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	GINS4	Q9BRT9	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	GINS4	Q9BRT9	SIK1B	Homo sapiens	A0A0B4J2F2	Y2H Array	32296183
Intra	GINS4	Q9BRT9	SIK1B	Homo sapiens	A0A0B4J2F2	Y2H Prey Pooling	32296183
Intra	GINS4	Q9BRT9	BIN3	Homo sapiens	Q9NQY0	Y2H Prey Pooling	32296183
Intra	GINS4	Q9BRT9	BIN3	Homo sapiens	Q9NQY0	Validated Y2H	32296183
Intra	GINS4	Q9BRT9	BIN3	Homo sapiens	Q9NQY0	Y2H Array	32296183
Intra	GINS4	Q9BRT9	DMAP1	Homo sapiens	Q9NPF5	Y2H Prey Pooling	32296183
Intra	GINS4	Q9BRT9	DMAP1	Homo sapiens	Q9NPF5	Validated Y2H	32296183
Intra	GINS4	Q9BRT9	DMAP1	Homo sapiens	Q9NPF5	Y2H Array	32296183
Intra	GINS4	Q9BRT9	CTNNBIP1	Homo sapiens	Q9NSA3	Y2H Prey Pooling	32296183
Intra	GINS4	Q9BRT9	CTNNBIP1	Homo sapiens	Q9NSA3	Validated Y2H	32296183
Intra	GINS4	Q9BRT9	CTNNBIP1	Homo sapiens	Q9NSA3	Y2H Array	32296183
Intra	GINS4	Q9BRT9	GINS2	Homo sapiens	Q9Y248	Y2H Prey Pooling	32296183
Intra	GINS4	Q9BRT9	GINS2	Homo sapiens	Q9Y248	Y2H Array	25416956
Intra	GINS4	Q9BRT9	GINS2	Homo sapiens	Q9Y248	Y2H Array	32296183
Intra	GINS4	Q9BRT9	GINS2	Homo sapiens	Q9Y248	Validated Y2H	32296183
Intra	GINS4	Q9BRT9	GINS2	Homo sapiens	Q9Y248	Y2H Array	31515488
Intra	GINS4	Q9BRT9	GINS2	Homo sapiens	Q9Y248	Y2H Prey Pooling	25416956
Intra	GINS4	Q9BRT9	MCMBP	Homo sapiens	Q9BTE3	Anti Bait CoIP	22540012
Intra	GINS4	Q9BRT9	LHX8	Homo sapiens	Q68G74	Y2H Array	32296183
Intra	GINS4	Q9BRT9	LHX8	Homo sapiens	Q68G74	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Adrenal Cortical Adenocarcinoma	Adrenal Cortex Adenocarcinoma Adrenocortical Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05433	GINS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20936	Gins1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GINS4	VGNC	VGNC:41223
Mus musculus	GINS4	MGD	MGI:1923847
Rattus norvegicus	GINS4	RGD	RGD:1307397
Bos taurus	GINS4	VGNC	VGNC:29363
Felis catus	GINS4	VGNC	VGNC:62556
Macaca mulatta	GINS4	VGNC	VGNC:73021
Others	GINS4	NCBI