GINS2 - GINS complex subunit 2 Gene

Also Known as PSF2; Pfs2; HSPC037

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51659

About GINS2

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:85,676,198-85,688,954 (from NCBI)

This gene has 3 transcripts (splice variants) and 208 orthologues. Broad expression in bone marrow (RPKM 11.1), lymph node (RPKM 10.1) and 20 other tissues.

Summary

The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

GINS2 Products (1)

mRNA Protein Name
NM_016095.3 NP_057179.1 DNA replication complex GINS protein PSF2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA unwinding involved in DNA replication IDA
IDA: Inferred from direct assay
22474384 GOA
Cellular Component GO Annotation Evidence References Source
part of CMG complex IPI
IPI: Inferred from physical interaction
22474384 GOA
part of GINS complex IPI
IPI: Inferred from physical interaction
17417653 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22474384 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GINS2 Protein Structure

Sld5

Sld5: GINS complex protein (42 - 153)

  • 0
  • 100
  • 185 a.a.
Protein Preferred Names Protein Names

DNA replication complex GINS protein PSF2

  • GINS complex subunit 2 (Psf2 homolog)

GINS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GINS2 Q9Y248 GINS4 Homo sapiens Q9BRT9
Validated Y2H
25416956
Intra
GINS2 Q9Y248 GINS4 Homo sapiens Q9BRT9
Anti Tag CoIP
33961781
Intra
GINS2 Q9Y248 GINS4 Homo sapiens Q9BRT9
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colon Small Cell Carcinoma

  • Colonic Small Cell Carcinoma

  • Colon Small Cell Neuroendocrine Carcinoma
Meier-Gorlin Syndrome 5

  • MGORS5

  • Meier-Gorlin Syndrome, Type 5
Paronychia

  • Paronychia Inflammation

  • Onychomycosis

  • Fungal Nail Infection

  • Infected Nailfold

  • Onychia And Paronychia Of Finger

  • Onychia And Paronychia Of Toe

  • Fungal Infection Of The Nails
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05431 GINS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22525 Gins2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29046 Gins2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GINS2 VGNC VGNC:99509
Canis familiaris GINS2 VGNC VGNC:41221
Bos taurus GINS2 VGNC VGNC:29361
Felis catus GINS2 VGNC VGNC:62554
Mus musculus GINS2 MGD MGI:1921019
Rattus norvegicus GINS2 RGD RGD:1311055
Others GINS2 NCBI