LDB1 - LIM domain binding 1 Gene

Also Known as NLI; CLIM2; LDB-1; CLIM-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8861

About LDB1

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,102,088-102,121,442 (from NCBI)

This gene has 4 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 42.1), ovary (RPKM 38.8) and 25 other tissues.

Summary

Enables LIM domain binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and enzyme binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Located in chromatin. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]

LDB1 Products (3)

mRNA Protein Name
NM_001113407.3 NP_001106878.1 LIM domain-binding protein 1 isoform 1
NM_001321612.2 NP_001308541.1 LIM domain-binding protein 1 isoform 2
NM_003893.5 NP_003884.1 LIM domain-binding protein 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
32417234 GOA
enables LIM domain binding IPI
IPI: Inferred from physical interaction
12792813 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16314316 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12792813 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10767331 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20855495 GOA
Cellular Component GO Annotation Evidence References Source
part of beta-catenin-TCF complex IDA
IDA: Inferred from direct assay
28296634 GOA
located in chromatin IDA
IDA: Inferred from direct assay
20855495 GOA
part of transcription regulator complex IDA
IDA: Inferred from direct assay
16314316 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDB1 Protein Structure

LIM_bind

LIM_bind: LIM-domain binding protein (69 - 272)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

LIM domain-binding protein 1

  • LIM domain-binding factor CLIM2

LDB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LDB1 Q86U70 LMX1B Homo sapiens O60663-2
Validated Y2H
25416956
Intra
LDB1 Q86U70 LHX6 Homo sapiens Q9UPM6
Y2H Prey Pooling
25416956
Intra
LDB1 Q86U70 LHX2 Homo sapiens P50458
Y2H Array
20211142
Intra
LDB1 Q86U70 SYNGAP1 Homo sapiens Q96PV0
Anti Bait CoIP
37207277
Intra
LDB1 Q86U70 LMO4 Homo sapiens P61968
Y2H Prey Pooling
25416956
Intra
LDB1 Q86U70 LMO4 Homo sapiens P61968
Y2H Array
25416956
Intra
LDB1 Q86U70 LMX1B Homo sapiens O60663
Y2H
12792813
Intra
LDB1 Q86U70 LMO2 Homo sapiens P25791
Validated Y2H
25416956
Intra
LDB1 Q86U70 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
LDB1 Q86U70 LMO3 Homo sapiens Q8TAP4
Y2H Pooling
16189514
Intra
LDB1 Q86U70 LMO3 Homo sapiens Q8TAP4
Y2H Array
20211142
Intra
LDB1 Q86U70 SSBP4 Homo sapiens Q9BWG4
Y2H Pooling
16189514
Intra
LDB1 Q86U70 SSBP2 Homo sapiens P81877
Y2H Pooling
16189514
Intra
LDB1 Q86U70 LHX8 Homo sapiens Q68G74
Validated Y2H
25416956
Intra
LDB1 Q86U70 LHX8 Homo sapiens Q68G74
Y2H Prey Pooling
25416956
Intra
LDB1 Q86U70 LMO1 Homo sapiens P25800
Y2H Array
25416956
Intra
LDB1 Q86U70 LMO1 Homo sapiens P25800
Y2H Prey Pooling
25416956
Intra
LDB1 Q86U70 LMO1 Homo sapiens P25800
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nail-Patella Syndrome

  • Turner-Kieser Syndrome

  • Onychoosteodysplasia

  • Fong Disease

  • NPS

  • Hereditary Onycho-Osteodysplasia

  • Nps1

  • Hereditary Onychoostedysplasia

  • Iliac Horn Syndrome

  • Nail Patella Syndrome

  • Turner-Kiser Syndrome

  • Arthro-Onychodysplasia

  • Nps 1

  • Osteo-Onychodysplasia

  • Hereditary Osteo-Onychodysplasia

  • Osterreicher Syndrome

  • Pelvic Horn Syndrome

  • Österreicher-Turner Syndrome

  • Nps - [Nail-Patella Syndrome]

  • Hood - [Hereditary Onycho-Osteodysplasia] Syndrome
Brain Stem Infarction

  • Brain Stem Infarctions

  • Brainstem Infarction
Neurogenic Bowel
Quadriplegia

  • Tetraplegia

  • Tetraplegias
Plexopathy
Acute Erythroid Leukemia

  • Acute Erythroleukemia

  • Di Guglielmo'S Syndrome

  • Aml M6

  • Acute Myeloid Leukemia Fab-M6

  • Acute Myeloid Leukemia M6

  • Erythroleukemia

  • Aml-M6

  • Acute Erythroleukemia M6a Subtype

  • Acute Erythroleukemia M6b Subtype

  • Di Guglielmo Syndrome

  • Acute Myeloid Leukemia, M6 Type

  • Acute Erythroblastic Leukemia

  • Acute Erythroleukemia - M6a Subtype

  • Acute Erythroleukemia - M6b Subtype

  • Acute Erythraemia And Erythroleukaemia

  • Acute Erythroid Leukaemia Without Mention Of Remission

  • Erythraemia

  • Erythraemic Myelosis

  • Erythroleukaemia

  • Acute Erythraemic Myelosis

  • Acute Erythraemia
Fetal Hemoglobin Quantitative Trait Locus 1

  • Hereditary Persistence Of Fetal Hemoglobin

  • Delta-Beta-Thalassemia

  • Delta-Beta Thalassemia

  • Delta Beta-Thalassemia

  • HBFQTL1

  • Hemoglobin F, Hereditary Persistence Of

  • Hpfh

  • Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related

  • Hemoglobin, Fetal, Quantitative Trait Locus 1

  • Hereditary Persistence Of Fetal Hemoglobin Thalassemia

  • Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]

  • Fetal Haemoglobin

  • Persistence Of Fetal Haemoglobin

  • Persistent Haemoglobin F
Hemoglobinopathy

  • Hemoglobinopathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07568 LDB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07569 LDB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19348 Ldb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25839 Ldb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LDB1 VGNC VGNC:68027
Macaca mulatta LDB1 VGNC VGNC:74245
Canis familiaris LDB1 VGNC VGNC:42618
Bos taurus LDB1 VGNC VGNC:55957
Mus musculus LDB1 MGD MGI:894762
Rattus norvegicus LDB1 RGD RGD:1310359
Others LDB1 NCBI