ZMYND10 - zinc finger MYND-type containing 10 Gene

Also Known as BLU; FLU; CILD22; DNAAF7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51364

About ZMYND10

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,341,112-50,345,732 (from NCBI)

This gene has 9 transcripts (splice variants), 194 orthologues, 2 paralogues and is associated with 3 phenotypes. Restricted expression toward testis (RPKM 91.8).

Summary

This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in Cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

ZMYND10 Products (2)

mRNA Protein Name
NM_001308379.2 NP_001295308.1 zinc finger MYND domain-containing protein 10 isoform 2
NM_015896.4 NP_056980.2 zinc finger MYND domain-containing protein 10 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in inner dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23891469 GOA
involved in motile cilium assembly IMP
IMP: Inferred from mutant phenotype
23891469 GOA
involved in outer dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23891469 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYND10 Protein Structure

zf-MYND

zf-MYND: MYND finger (394 - 430)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

zinc finger MYND domain-containing protein 10

  • Ciliary dyskinesia, primary, 22

ZMYND10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZMYND10 O75800 NUTM1 Homo sapiens Q86Y26
Validated Y2H
25416956
Intra
ZMYND10 O75800 NUTM1 Homo sapiens Q86Y26
Y2H Prey Pooling
25416956
Intra
ZMYND10 O75800 FAM22F Homo sapiens B7ZLH0
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 FAM22F Homo sapiens B7ZLH0
Y2H Array
32296183
Intra
ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Y2H Array
32296183
Intra
ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Validated Y2H
32296183
Intra
ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Validated Y2H
32296183
Intra
ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Y2H Array
32296183
Intra
ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Validated Y2H
32296183
Intra
ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
ZMYND10 O75800 CDR1 Homo sapiens P51861
Y2H Array
32296183
Intra
ZMYND10 O75800 CDR1 Homo sapiens P51861
Validated Y2H
32296183
Intra
ZMYND10 O75800 CDR1 Homo sapiens P51861
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 TBX5 Homo sapiens Q99593
Y2H Array
32296183
Intra
ZMYND10 O75800 TBX5 Homo sapiens Q99593
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 TBX5 Homo sapiens Q99593
Validated Y2H
32296183
Intra
ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Validated Y2H
32296183
Intra
ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Y2H Array
32296183
Intra
ZMYND10 O75800 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Validated Y2H
32296183
Intra
ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Y2H Array
32296183
Intra
ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
25416956
Intra
ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
25416956
Intra
ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Pooling
16189514
Intra
ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Pull Down
16189514
Intra
ZMYND10 O75800 RBM11 Homo sapiens P57052
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 RBM11 Homo sapiens P57052
Validated Y2H
32296183
Intra
ZMYND10 O75800 RBM11 Homo sapiens P57052
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 22

  • Primary Ciliary Dyskinesia 22

  • CILD22

  • Primary Ciliary Dyskinesia 22 With Or Without Situs Inversus

  • Ciliary Dyskinesia, Primary, 22, With Or Without Situs Inversus

  • Dyskinesia, Ciliary, Primary, 22
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Kartagener Syndrome

  • Kartagener'S Syndrome
Nasopharyngeal Carcinoma

  • Malignant Neoplasm Of Nasopharynx

  • Npc

  • Nasopharyngeal Cancer

  • Nasopharyngeal Carcinoma 1

  • Nasopharynx Carcinoma

  • Nasopharyngeal Neoplasms

  • Npca

  • Carcinoma Of Nasopharynx

  • Malignant Nasopharyngeal Tumor

  • Nasopharynx Cancer

  • Squamous Cell Carcinoma Of The Nasopharynx

  • Nasopharyngeal Neoplasm

  • Cancer Of Nasopharynx
Situs Inversus

  • Situs Inversus Viscerum

  • Laterality Sequence

  • Complete Transposition

  • Siv
Acute Endometritis
Spondylometaphyseal Dysplasia With Cone-Rod Dystrophy

  • Spondylometaphyseal Dysplasia-Cone-Rod Dystrophy Syndrome

  • SMDCRD

  • Smd-Crd

  • Dysplasia, Spondylometaphyseal, With Cone-Rod Dystrophy
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16093 ZMYND10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZMYND10 RGD RGD:1303250
Canis familiaris ZMYND10 VGNC VGNC:48650
Felis catus ZMYND10 VGNC VGNC:67263
Mus musculus ZMYND10 MGD MGI:2387863
Bos taurus ZMYND10 VGNC VGNC:37201
Macaca mulatta ZMYND10 VGNC VGNC:79195
Others ZMYND10 NCBI