NRF1 - nuclear respiratory factor 1 Gene

Also Known as ALPHA-PAL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4899

About NRF1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:129,611,720-129,757,076 (from NCBI)

This gene has 7 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in ovary (RPKM 7.4), lymph node (RPKM 5.2) and 25 other tissues.

Summary

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

NRF1 Products (4)

mRNA Protein Name
NM_001040110.2 NP_001035199.1 nuclear respiratory factor 1 isoform 1
NM_001293163.2 NP_001280092.1 nuclear respiratory factor 1 isoform 2
NM_001293164.2 NP_001280093.1 nuclear respiratory factor 1 isoform 3
NM_005011.5 NP_005002.3 nuclear respiratory factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19674972 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
19674972 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19674972 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16864783 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19674972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRF1 Protein Structure

Nrf1_DNA-bind

Nrf1_DNA-bind: NLS-binding and DNA-binding and dimerisation domains of Nrf1 (75 - 285)

Nrf1_activ_bdg

Nrf1_activ_bdg: Nrf1 activator activation site binding domain (450 - 490)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

nuclear respiratory factor 1

  • alpha palindromic-binding protein

NRF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NRF1 Q16656 SP4 Homo sapiens Q02446
Y2H Array
25416956
Intra
NRF1 Q16656 SP4 Homo sapiens Q02446
Y2H Prey Pooling
25416956
Intra
NRF1 Q16656 POGZ Homo sapiens Q7Z3K3
Y2H Array
25416956
Intra
NRF1 Q16656 POGZ Homo sapiens Q7Z3K3
Validated Y2H
25416956
Intra
NRF1 Q16656 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
NRF1 Q16656 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra
NRF1 Q16656 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
25416956
Intra
NRF1 Q16656 FHL2 Homo sapiens Q14192
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

NRF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80769 NRF-1 Antibody (YA260) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P80769A NRF-1 Antibody (YA260)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P85571 NRF-1 Antibody (YA5263) WB Human
HY-P86199 NRF-1 Antibody (YA5891) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Oncocytoma

  • Oxyphilic Adenoma

  • Follicular Adenoma, Oxyphilic Cell

  • Adenoma, Oxyphilic

  • Hurthle Cell Tumor

  • Oncocytic Neoplasm
Skin Carcinoma In Situ

  • Carcinoma In Situ Of Skin

  • Cutaneous Carcinoma In Situ
Benign Peritoneal Mesothelioma

  • Mesothelioma Of Peritoneum

  • Benign Neoplasm Of Mesothelial Tissue Of Peritoneum
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diabetes Mellitus

  • Diabetes
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129225 WRR139 Inhibitor 99.71% Unkown
HY-149127 Rosolutamide 99.03% Unkown
HY-RS09567 NRF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125535 OSU-53 / Unkown
HY-184160 Mcl1 Degrader-1 / Unkown
HY-RS09244 NFE2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17333 Nrf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21165 Nfe2l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23788 Nrf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NRF1 VGNC VGNC:43966
Rattus norvegicus NRF1 RGD RGD:1304603
Macaca mulatta NRF1 VGNC VGNC:81731
Mus musculus NRF1 MGD MGI:1332235
Felis catus NRF1 VGNC VGNC:68563
Bos taurus NRF1 VGNC VGNC:32260
Others NRF1 NCBI