POU2F1 - POU class 2 homeobox 1 Gene

Also Known as OCT1; OTF1; Oct1Z; oct-1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5451

About POU2F1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:167,220,885-167,427,345 (from NCBI)

This gene has 17 transcripts (splice variants), 239 orthologues and 17 paralogues. Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 2.3) and 25 other tissues.

Summary

The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

POU2F1 Products (5)

mRNA	Protein	Name
NM_001198783.2	NP_001185712.1	POU domain, class 2, transcription factor 1 isoform 2
NM_001198786.2	NP_001185715.1	POU domain, class 2, transcription factor 1 isoform 3
NM_001365848.1	NP_001352777.1	POU domain, class 2, transcription factor 1 isoform 4
NM_001365849.1	NP_001352778.1	POU domain, class 2, transcription factor 1 isoform 4
NM_002697.4	NP_002688.3	POU domain, class 2, transcription factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9199328	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11380252	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25802280	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	10329190	GOA
enables RNA polymerase II core promoter sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	10541551	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10629049	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7945330	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11891224	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11997177	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15252056	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	11380252	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11380252	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IMP IMP: Inferred from mutant phenotype	10329190	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9242494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU2F1 Protein Structure

Pou

Homeobox

0
200
400
600
743 a.a.

Protein Preferred Names	Protein Names
POU domain, class 2, transcription factor 1	NF-A1

POU2F1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POU2F1	P14859	SP4	Homo sapiens	Q02446	Y2H Prey Pooling	25416956
Intra	POU2F1	P14859	SP4	Homo sapiens	Q02446	Validated Y2H	25416956
Intra	POU2F1	P14859	SP4	Homo sapiens	Q02446	Y2H Array	25416956
Intra	POU2F1	P14859	POGZ	Homo sapiens	Q7Z3K3	Y2H Prey Pooling	25416956
Intra	POU2F1	P14859	POGZ	Homo sapiens	Q7Z3K3	Validated Y2H	25416956
Intra	POU2F1	P14859	SP1	Homo sapiens	P08047	Anti Tag CoIP	19070619
Intra	POU2F1	P14859	SP1	Homo sapiens	P08047	Anti Bait CoIP	19070619
Intra	POU2F1	P14859	SP1	Homo sapiens	P08047	Pull Down	19070619
Intra	POU2F1	P14859	SP1	Homo sapiens	P08047	Y2H	10976766
Intra	POU2F1	P14859	PLK3	Homo sapiens	Q9H4B4	Y2H Prey Pooling	25416956
Intra	POU2F1	P14859	PLK3	Homo sapiens	Q9H4B4	Validated Y2H	25416956
Intra	POU2F1	P14859	PLK3	Homo sapiens	Q9H4B4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

POU2F1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85672	OCT1 Antibody (YA5364)	WB, IHC-P, ICC/IF,	Human

Related Diseases

Diseases	Alias
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Hypotrichosis 3	HYPT3 Hypotrichosis Simplex Of The Scalp 2 Htss2 Hypotrichosis, Type 3
Primary Amebic Meningoencephalitis	Pam Naegleria Fowleri Infection Meningoencephalitis Caused By Naegleria Fowleri Primary Amoebic Meningoencephalitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10897	POU2F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174788	HHV-1 UL48 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POU2F1	RGD	RGD:621689
Mus musculus	POU2F1	MGD	MGI:101898
Macaca mulatta	POU2F1	VGNC	VGNC:76223
Canis familiaris	POU2F1	VGNC	VGNC:44826
Felis catus	POU2F1	VGNC	VGNC:68964
Bos taurus	POU2F1	VGNC	VGNC:33174
Others	POU2F1	NCBI