PLK3 - polo like kinase 3 Gene

Also Known as CNK; FNK; PRK; PLK-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1263

About PLK3

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,800,377-44,805,990 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 16.1), gall bladder (RPKM 12.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during Mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by Apoptosis. [provided by RefSeq, Sep 2015]

PLK3 Products (3)

mRNA	Protein	Name
NM_004073.4	NP_004064.2	serine/threonine-protein kinase PLK3
XM_047444455.1	XP_047300411.1	serine/threonine-protein kinase PLK3 isoform X1
XM_047444463.1	XP_047300419.1	serine/threonine-protein kinase PLK3 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables p53 binding	IDA IDA: Inferred from direct assay	11447225	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14968113	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11447225	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	19490146	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	16481012	GOA
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17264206	GOA
involved in Golgi disassembly	IDA IDA: Inferred from direct assay	14980500	GOA
involved in cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	20951827	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19490146	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19490146	GOA
involved in positive regulation of chaperone-mediated autophagy	IDA IDA: Inferred from direct assay	27344333	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	20951827	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	20889502	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20951827	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16478733	GOA
involved in response to osmotic stress	IDA IDA: Inferred from direct assay	21098032	GOA
involved in response to radiation	IDA IDA: Inferred from direct assay	21376736	GOA
involved in response to reactive oxygen species	IDA IDA: Inferred from direct assay	11447225	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi stack	IDA IDA: Inferred from direct assay	14980500	GOA
located in centrosome	IDA IDA: Inferred from direct assay	16478733	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19490146	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	17264206	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19490146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLK3 Protein Structure

Pkinase

POLO_box

0
100
200
300
400
500
600
646 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PLK3	FGF-inducible kinase cytokine-inducible serine/threonine-protein kinase proliferation-related kinase

PLK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLK3	Q9H4B4	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	PLK3	Q9H4B4	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	PLK3	Q9H4B4	VRK1	Homo sapiens	Q99986	Confocal	19103756
Intra	PLK3	Q9H4B4	VRK1	Homo sapiens	Q99986	Pull Down	19103756
Intra	PLK3	Q9H4B4	VRK1	Homo sapiens	Q99986	Protein Kinase Assay	19103756
Intra	PLK3	Q9H4B4	LSM5	Homo sapiens	Q9Y4Y9	Y2H Prey Pooling	32296183
Intra	PLK3	Q9H4B4	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	32296183
Intra	PLK3	Q9H4B4	LSM5	Homo sapiens	Q9Y4Y9	Y2H Array	32296183
Intra	PLK3	Q9H4B4	RNF141	Homo sapiens	Q8WVD5	Y2H Prey Pooling	32296183
Intra	PLK3	Q9H4B4	RNF141	Homo sapiens	Q8WVD5	Y2H Array	32296183
Intra	PLK3	Q9H4B4	RAD52	Homo sapiens	P43351	Y2H Array	32296183
Intra	PLK3	Q9H4B4	RAD52	Homo sapiens	P43351	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hermansky-Pudlak Syndrome 1	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells HPS1 Delta Storage Pool Disease Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Hermansky-Pudlak Syndrome, Type 1 Platelet Storage Pool Deficiency
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Parkinson Disease 6, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 6 Parkinson Disease 6 PARK6 Parkinson Disease 6, Early Onset Parkinson'S Disease 6 Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1 Parkinson Disease 6, Early-Onset Autosomal Recessive Early-Onset Parkinson'S Disease 6 Early-Onset Parkinson Disease 6 Autosomal Recessive Early-Onset Parkinson Disease Type 6 Parkinson Disease 6 Early-Onset Parkinson Disease 6 Late-Onset Susceptibility To Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1 Parkinsonism Young Adult Onset Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Anal Squamous Cell Carcinoma	Epidermoid Anal Carcinoma Carcinoma Of Anal Margin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12137	Volasertib	Inhibitor	99.97%	Yes
HY-12137A	Volasertib trihydrochloride	Inhibitor	99.12%	Yes

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50698	BI 2536	Inhibitor	99.95%	Phase 2
HY-147298	Plogosertib	Inhibitor	98.59%	Phase 2
HY-15160	TAK-960	Inhibitor	99.75%	Phase 1
HY-15160B	TAK-960 dihydrochloride	Inhibitor	99.15%	Phase 1
HY-15160A	TAK-960 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10197	Wortmannin	Inhibitor	99.86%	Unkown
HY-100789	ON1231320	Inhibitor	99.90%	Unkown
HY-11003	GW843682X	Inhibitor	99.89%	Unkown
HY-12134	Poloxin	Inhibitor	98.05%	Unkown
HY-108597	TC-S 7005	Inhibitor	99.68%	Unkown
HY-15158	SBE13 Hydrochloride	Inhibitor	98.56%	Unkown
HY-18009	(Z)-LFM-A13	Inhibitor	99.80%	Unkown
HY-110002	LFM-A13	Inhibitor	99.65%	Unkown
HY-173212	PLK1-IN-13	Inhibitor	/	Unkown
HY-149100	PLK1-IN-6	Inhibitor	/	Unkown
HY-15158A	SBE13	Inhibitor	/	Unkown
HY-172364	PLK1-IN-12	Inhibitor	/	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown
HY-111090	GSK461364 analogue 1	Inhibitor	/	Unkown
HY-181051	PLK1-IN-16	Inhibitor	/	Unkown
HY-181030	BDE30671203	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLK3	RGD	RGD:62039
Felis catus	PLK3	VGNC	VGNC:64245
Macaca mulatta	PLK3	VGNC	VGNC:76092
Canis familiaris	PLK3	VGNC	VGNC:44697
Mus musculus	PLK3	MGD	MGI:109604
Bos taurus	PLK3	VGNC	VGNC:33035
Others	PLK3	NCBI