2. Gene
  3. PLK3 - polo like kinase 3 Gene

PLK3 - polo like kinase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CNK; FNK; PRK; PLK-3

Gene ID: 1263 | Gene type: protein coding

About PLK3

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,800,377-44,805,990 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 16.1), gall bladder (RPKM 12.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by Apoptosis. [provided by RefSeq, Sep 2015]

PLK3 Products(3)

mRNA Protein Name
NM_004073.4 NP_004064.2 serine/threonine-protein kinase PLK3
XM_047444455.1 XP_047300411.1 serine/threonine-protein kinase PLK3 isoform X1
XM_047444463.1 XP_047300419.1 serine/threonine-protein kinase PLK3 isoform X2

PLK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (64 - 314)

POLO_box

POLO_box: POLO box duplicated region (470 - 532)

POLO_box

POLO_box: POLO box duplicated region (568 - 636)

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  • 646 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK3

FGF-inducible kinase

cytokine-inducible serine/threonine-protein kinase

proliferation-related kinase

Related Diseases

Diseases Alias
Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

HPS1

Delta Storage Pool Disease

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Hermansky-Pudlak Syndrome, Type 1

Platelet Storage Pool Deficiency
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6

Parkinson Disease 6

PARK6

Parkinson Disease 6, Early Onset

Parkinson'S Disease 6

Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

Parkinson Disease 6, Early-Onset

Autosomal Recessive Early-Onset Parkinson'S Disease 6

Early-Onset Parkinson Disease 6

Autosomal Recessive Early-Onset Parkinson Disease Type 6

Parkinson Disease 6 Early-Onset

Parkinson Disease 6 Late-Onset Susceptibility To

Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1

Parkinsonism Young Adult Onset

Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Anal Squamous Cell Carcinoma

Epidermoid Anal Carcinoma

Carcinoma Of Anal Margin
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.41% Yes
HY-12137A Volasertib trihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10197 Wortmannin Inhibitor 99.86% Unkown
HY-11003 GW843682X Inhibitor 99.75% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.97% Unkown
HY-108597 TC-S 7005 Inhibitor 99.56% Unkown
HY-12134 Poloxin Inhibitor 98.01% Unkown
HY-15158 SBE13 Hydrochloride Inhibitor 99.66% Unkown
HY-110002 LFM-A13 Inhibitor / Unkown
HY-15158A SBE13 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLK3 RGD RGD:62039
Felis catus PLK3 VGNC VGNC:64245
Macaca mulatta PLK3 VGNC VGNC:76092
Canis familiaris PLK3 VGNC VGNC:44697
Mus musculus PLK3 MGD MGI:109604
Bos taurus PLK3 VGNC VGNC:33035