1. Cell Cycle/DNA Damage
  2. Polo-like Kinase (PLK)
  3. TC-S 7005

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively.

For research use only. We do not sell to patients.

TC-S 7005 Chemical Structure

TC-S 7005 Chemical Structure

CAS No. : 1082739-92-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 286 In-stock
Solution
10 mM * 1 mL in DMSO USD 286 In-stock
Solid
5 mg USD 260 In-stock
10 mg USD 416 In-stock
25 mg USD 750 In-stock
50 mg USD 1125 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TC-S 7005

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Description

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].

IC50 & Target[1]

PLK2

4 nM (IC50)

PLK3

24 nM (IC50)

PLK1

214 nM (IC50)

In Vitro

TC-S 7005 markedly induces myofibroblast differentiation and reduces fibroblast proliferation rates[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Primary human SR fibroblasts
Concentration: 1 μM
Incubation Time: 7 days
Result: Markedly induced myofibroblast differentiation and reduced fibroblast proliferation rates.
Molecular Weight

359.38

Formula

C21H17N3O3

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@H](NC1=CC2=C(ON=C2C3=CC=C(OCO4)C4=C3)C=N1)C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (347.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7826 mL 13.9128 mL 27.8257 mL
5 mM 0.5565 mL 2.7826 mL 5.5651 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.56%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7826 mL 13.9128 mL 27.8257 mL 69.5642 mL
5 mM 0.5565 mL 2.7826 mL 5.5651 mL 13.9128 mL
10 mM 0.2783 mL 1.3913 mL 2.7826 mL 6.9564 mL
15 mM 0.1855 mL 0.9275 mL 1.8550 mL 4.6376 mL
20 mM 0.1391 mL 0.6956 mL 1.3913 mL 3.4782 mL
25 mM 0.1113 mL 0.5565 mL 1.1130 mL 2.7826 mL
30 mM 0.0928 mL 0.4638 mL 0.9275 mL 2.3188 mL
40 mM 0.0696 mL 0.3478 mL 0.6956 mL 1.7391 mL
50 mM 0.0557 mL 0.2783 mL 0.5565 mL 1.3913 mL
60 mM 0.0464 mL 0.2319 mL 0.4638 mL 1.1594 mL
80 mM 0.0348 mL 0.1739 mL 0.3478 mL 0.8696 mL
100 mM 0.0278 mL 0.1391 mL 0.2783 mL 0.6956 mL
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TC-S 7005 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TC-S 7005
Cat. No.:
HY-108597
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