1. Cell Cycle/DNA Damage
  2. Polo-like Kinase (PLK)
  3. TC-S 7005

TC-S 7005 

Cat. No.: HY-108597 Purity: 99.56%
COA Handling Instructions

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively.

For research use only. We do not sell to patients.

TC-S 7005 Chemical Structure

TC-S 7005 Chemical Structure

CAS No. : 1082739-92-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 396 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 396 In-stock
5 mg USD 360 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TC-S 7005

View All Polo-like Kinase (PLK) Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].

IC50 & Target[1]


4 nM (IC50)


24 nM (IC50)


214 nM (IC50)

In Vitro

TC-S 7005 markedly induces myofibroblast differentiation and reduces fibroblast proliferation rates[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Primary human SR fibroblasts
Concentration: 1 μM
Incubation Time: 7 days
Result: Markedly induced myofibroblast differentiation and reduced fibroblast proliferation rates.
Molecular Weight







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Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (347.82 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7826 mL 13.9128 mL 27.8257 mL
5 mM 0.5565 mL 2.7826 mL 5.5651 mL
10 mM 0.2783 mL 1.3913 mL 2.7826 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.56%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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