TC-S 7005

Name: TC-S 7005
Brand: MedChemExpress
SKU: HY-108597
Rating: 5.0 (4 reviews)

Cat. No.: HY-108597 Pureza: 99.68%: Ficha de datos
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TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC₅₀s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively.

Para uso exclusivo en investigación. No vendemos a pacientes.

TC-S 7005 Estructura química

No. CAS : 1082739-92-1

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 4 publication(s) in Google Scholar

4 Publications Citing Use of MCE TC-S 7005

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Polo-like Kinase (PLK):

Ver todas las isoformas

PLK1 PLK2 PLK3 PLK4

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC₅₀s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively^[1].

IC₅₀ & Target^[1]

PLK2

4 nM (IC₅₀)

PLK3

24 nM (IC₅₀)

PLK1

214 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	7.32 μM Compound: 9	Cell cycle arrest in human HCT 116 cells assessed as doubling of DNA content by high-content cell screening assay Cell cycle arrest in human HCT 116 cells assessed as doubling of DNA content by high-content cell screening assay	[PMID: 18790636]

In Vitro

TC-S 7005 markedly induces myofibroblast differentiation and reduces fibroblast proliferation rates^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	Primary human SR fibroblasts
Concentration:	1 μM
Incubation Time:	7 days
Result:	Markedly induced myofibroblast differentiation and reduced fibroblast proliferation rates.

Peso molecular

359.38

Fòrmula

C₂₁H₁₇N₃O₃

No. CAS

1082739-92-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@H](NC1=CC2=C(ON=C2C3=CC=C(OCO4)C4=C3)C=N1)C5=CC=CC=C5

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (347.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7826 mL	13.9128 mL	27.8257 mL
5 mM	0.5565 mL	2.7826 mL	5.5651 mL
10 mM	0.2783 mL	1.3913 mL	2.7826 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.68%

Select Batch:

Ficha de datos (275 KB) SDS (251 KB)

COA (252 KB) LCMS (99 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Hanan EJ, et al. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5186-9. [Content Brief]

[2]. Stephan Reinhard Künzel, et al. Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation. bioRxiv 445098

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7826 mL	13.9128 mL	27.8257 mL	69.5642 mL
	5 mM	0.5565 mL	2.7826 mL	5.5651 mL	13.9128 mL
	10 mM	0.2783 mL	1.3913 mL	2.7826 mL	6.9564 mL
	15 mM	0.1855 mL	0.9275 mL	1.8550 mL	4.6376 mL
	20 mM	0.1391 mL	0.6956 mL	1.3913 mL	3.4782 mL
	25 mM	0.1113 mL	0.5565 mL	1.1130 mL	2.7826 mL
	30 mM	0.0928 mL	0.4638 mL	0.9275 mL	2.3188 mL
	40 mM	0.0696 mL	0.3478 mL	0.6956 mL	1.7391 mL
	50 mM	0.0557 mL	0.2783 mL	0.5565 mL	1.3913 mL
	60 mM	0.0464 mL	0.2319 mL	0.4638 mL	1.1594 mL
	80 mM	0.0348 mL	0.1739 mL	0.3478 mL	0.8696 mL
	100 mM	0.0278 mL	0.1391 mL	0.2783 mL	0.6956 mL

TC-S 7005 Related Classifications

Inflammation/Immunology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC-S 70051082739-92-1Polo-like Kinase (PLK)Inhibitorinhibitorinhibit

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TC-S 7005

Revisión del cliente

TC-S 7005 Related Antibodies

4 Publications Citing Use of MCE TC-S 7005

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Polo-like Kinase (PLK):

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

TC-S 7005 Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

TC-S 7005 Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

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SAFETY DATA SHEET (SDS)

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