1. Cell Cycle/DNA Damage
  2. Polo-like Kinase (PLK)
  3. TC-S 7005

TC-S 7005 

Cat. No.: HY-108597 Purity: >99.0%
Handling Instructions

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively.

For research use only. We do not sell to patients.

TC-S 7005 Chemical Structure

TC-S 7005 Chemical Structure

CAS No. : 1082739-92-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 396 In-stock
Estimated Time of Arrival: December 31
5 mg USD 360 In-stock
Estimated Time of Arrival: December 31
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Description

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].

IC50 & Target[1]

PLK2

4 nM (IC50)

PLK3

24 nM (IC50)

PLK1

214 nM (IC50)

In Vitro

TC-S 7005 markedly induces myofibroblast differentiation and reduces fibroblast proliferation rates[2].

Cell Proliferation Assay[2]

Cell Line: Primary human SR fibroblasts
Concentration: 1 μM
Incubation Time: 7 days
Result: Markedly induced myofibroblast differentiation and reduced fibroblast proliferation rates.
Molecular Weight

359.38

Formula

C₂₁H₁₇N₃O₃

CAS No.

1082739-92-1

SMILES

C[[email protected]](NC1=CC2=C(ON=C2C3=CC=C(OCO4)C4=C3)C=N1)C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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TC-S 7005
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