Wrightiadione
Wrightiadione is a selective natural tetracyclic isoflavone kinase inhibitor with inhibitory activity against TrkA and PLK3. The IC50 values of Wrightiadione against TrkA and PLK3 are 55.8 μM and 9.0 μM, respectively. Wrightiadione is found in the dried bark of Wrightia tomentosa. Wrightiadione can be used in studies of leukemia, kinase inhibition and cancer-related signaling pathways.
For research use only. We do not sell to patients.
- CAS No.: 148180-61-4
- Formula: C16H8O3
- Molecular Weight:248.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
TrkA 55.8 μM (IC50) |
PLK3 9 μM (IC50) |
In Vitro
Wrightiadione (compound 1) at 10 μM selectively inhibits TrkA and PLK3 against a kinome panel consisting of 97 cancer-related kinases in a high-throughput binding assay[1].
Wrightiadione inhibits the activity of purified TrkA kinase in radiokinase assays, with an IC50 value of 55.8 μM[1].
Wrightiadione inhibits the kinase activity of purified PLK3 in radiometric kinase assays, with an IC50 of 9.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 148180-61-4
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Molecular Weight 248.24
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Formula C16H8O3
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SMILES
O=C1C=2OC=3C=CC=CC3C(=O)C2C=4C=CC=CC14
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Wrightiadione Related Classifications
HY-N15384 Related Classifications
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