148180-61-4
148180-61-4
Chemical Structure
Wrightiadione
- CAS No.: 148180-61-4
- Formula:C16H8O3
- Molecular Weight:248.24
IUPAC Name: indeno[2,1-b]chromene-6,11-dione
InChIKey: CXXCRLLJRGEAJV-UHFFFAOYSA-N
SMILES: O=C1C=2OC=3C=CC=CC3C(=O)C2C=4C=CC=CC14
Biological Activity: Wrightiadione is a selective natural tetracyclic isoflavone kinase inhibitor with inhibitory activity against TrkA and PLK3. The IC50 values of Wrightiadione against TrkA and PLK3 are 55.8 μM and 9.0 μM, respectively. Wrightiadione is found in the dried bark of Wrightia tomentosa. Wrightiadione can be used in studies of leukemia, kinase inhibition and cancer-related signaling pathways[1].
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Wrightiadione | Wrightiadione is a selective natural tetracyclic isoflavone kinase inhibitor with inhibitory activity against TrkA and PLK3. The IC50 values of Wrightiadione against TrkA and PLK3 are 55.8 μM and 9.0 μM, respectively. Wrightiadione is found in the dried bark of Wrightia tomentosa. Wrightiadione can be used in studies of leukemia, kinase inhibition and cancer-related signaling pathways. | |||||||||||||||||||||
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