SYPL1 - synaptophysin like 1 Gene

Also Known as SYPL; H-SP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6856

About SYPL1

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:106,090,505-106,112,576 (from NCBI)

This gene has 10 transcripts (splice variants), 236 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 63.3), esophagus (RPKM 56.9) and 25 other tissues.

Summary

Predicted to be involved in chemical synaptic transmission. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SYPL1 Products (13)

mRNA Protein Name
NM_001381910.1 NP_001368839.1 synaptophysin-like protein 1 isoform c
NM_001381911.1 NP_001368840.1 synaptophysin-like protein 1 isoform d
NM_001381912.1 NP_001368841.1 synaptophysin-like protein 1 isoform e
NM_001381913.1 NP_001368842.1 synaptophysin-like protein 1 isoform f
NM_001381915.1 NP_001368844.1 synaptophysin-like protein 1 isoform g
NM_001381916.1 NP_001368845.1 synaptophysin-like protein 1 isoform h
NM_001381917.1 NP_001368846.1 synaptophysin-like protein 1 isoform i precursor
NM_001381918.1 NP_001368847.1 synaptophysin-like protein 1 isoform j
NM_001381919.1 NP_001368848.1 synaptophysin-like protein 1 isoform j
NM_001381920.1 NP_001368849.1 synaptophysin-like protein 1 isoform k
NM_001381921.1 NP_001368850.1 synaptophysin-like protein 1 isoform k
NM_006754.5 NP_006745.1 synaptophysin-like protein 1 isoform a
NM_182715.4 NP_874384.1 synaptophysin-like protein 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29547901 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYPL1 Protein Structure

MARVEL

MARVEL: Membrane-associating domain (29 - 231)

  • 0
  • 100
  • 200
  • 259 a.a.
Protein Preferred Names Protein Names

synaptophysin-like protein 1

  • pantophysin

SYPL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SYPL1 Q16563 TEX44 Homo sapiens Q53QW1
Validated Y2H
32296183
Intra
SYPL1 Q16563 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
SYPL1 Q16563 TARS2 Homo sapiens Q9BW92
Validated Y2H
32296183
Intra
SYPL1 Q16563 ARFGAP3 Homo sapiens Q9NP61
Validated Y2H
32296183
Intra
SYPL1 Q16563 RBFA Homo sapiens Q8N0V3
Validated Y2H
32296183
Intra
SYPL1 Q16563 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SYPL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82379 Synaptophysin Like Protein 1 Antibody (YA2124) WB, IHC-P Human
HY-P82379A Synaptophysin Like Protein 1 Antibody (YA2124)(PBS only) WB, IHC-P Human

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 35

  • MRD35

  • Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome

  • Autosomal Dominant Non-Syndromic Intellectual Disability 35

  • Mental Retardation, Autosomal Dominant 35

  • Autosomal Dominant Intellectual Developmental Disorder 35

  • Autosomal Dominant Mental Retardation 35

  • Mental Retardation, Autosomal Dominant, Type 35
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14103 SYPL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SYPL1 VGNC VGNC:53679
Mus musculus SYPL1 MGD MGI:108081
Canis familiaris SYPL1 VGNC VGNC:47039
Macaca mulatta SYPL1 VGNC VGNC:78073
Rattus norvegicus SYPL1 RGD RGD:1359569
Others SYPL1 NCBI