[8]-Shogaol
Based on 4 publication(s) in Google Scholar
[8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC50=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC50=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC50=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.85%
- No. CAS: 36700-45-5
- Fòrmula: C19H28O3
- Peso molecular:304.42
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
![[8]-Shogaol Chemical Structure](https://file.medchemexpress.com/product_pic/hy-n2435.gif "Click to View [8]-Shogaol Chemical Structure")
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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[8]-Shogaol (Standard)COX Inhibitor -
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Publications Citing Use of MedChemExpress (MCE) [8]-Shogaol
More
Actividad biológica
Descripciòn
IC50 & Target
[2]|
COX-2 17.5 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | ED50 |
8.8 μM
Compound: 10
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Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
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[PMID: 14980683] |
| PC-12 | ED50 |
5.9 μM
Compound: 10
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Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
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[PMID: 14980683] |
In Vitro
[8]-Shogaol (10-50 μM; 24 h) exhibits cytotoxic effects on HL-60 cell growth in a concentration-dependent manner[3].
[8]-Shogaol (10 μM; 24 h) inhibits TNF-α, IL-1β, and IL-17-mediated inflammation and cell migration in RA patient-derived FLS (RA-FLS) and 3D synovial synoviocytes[4].
[8]-Shogaol inhibit the activity of TAK1 by binding to the ATP-binding pocket of TAK1[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Chemical Information
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No. CAS 36700-45-5
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Appearance Liquid (Density: 1.013±0.06 g/cm3)
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Peso molecular 304.42
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Fòrmula C19H28O3
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Color Colorless to light yellow
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SMILES
CCCCCCC/C=C/C(CCC1=CC=C(O)C(OC)=C1)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Lipidomic analysis of plant-derived extracellular vesicles for guidance of potential anti-cancer therapy. [Abstract]2024 Dec 10:46:82-96. PMID: 39737211 -
Food Chem
2024 Sep 15:452:139425. PMID: 38744128 -
Pharm Biol
Potential pharmacological quality control markers in the traditional Japanese medicine Hangeshashinto: identifying anti-inflammatory ingredients through a cell-based bioassay and multicomponent analysis. [Abstract]2025 Dec;63(1):819-836. PMID: 41240012 -
ChemMedChem
Machine Learning-Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a. [Abstract]2025 May 5;20(9):e202400913. PMID: 39853697
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (328.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (8.21 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.21 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58(6):3847-54. [Content Brief]
[2]. van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. [Content Brief]
[3]. Nurtjahja-Tjendraputra E, et al. Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res. 2003;111(4-5):259-65. [Content Brief]
[4]. Jo S, et al. 8-Shogaol inhibits rheumatoid arthritis through targeting TAK1. Pharmacol Res. 2022 Apr;178:106176. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2849 mL | 16.4247 mL | 32.8494 mL | 82.1234 mL |
| 5 mM | 0.6570 mL | 3.2849 mL | 6.5699 mL | 16.4247 mL | |
| 10 mM | 0.3285 mL | 1.6425 mL | 3.2849 mL | 8.2123 mL | |
| 15 mM | 0.2190 mL | 1.0950 mL | 2.1900 mL | 5.4749 mL | |
| 20 mM | 0.1642 mL | 0.8212 mL | 1.6425 mL | 4.1062 mL | |
| 25 mM | 0.1314 mL | 0.6570 mL | 1.3140 mL | 3.2849 mL | |
| 30 mM | 0.1095 mL | 0.5475 mL | 1.0950 mL | 2.7374 mL | |
| 40 mM | 0.0821 mL | 0.4106 mL | 0.8212 mL | 2.0531 mL | |
| 50 mM | 0.0657 mL | 0.3285 mL | 0.6570 mL | 1.6425 mL | |
| 60 mM | 0.0547 mL | 0.2737 mL | 0.5475 mL | 1.3687 mL | |
| 80 mM | 0.0411 mL | 0.2053 mL | 0.4106 mL | 1.0265 mL | |
| 100 mM | 0.0328 mL | 0.1642 mL | 0.3285 mL | 0.8212 mL |
[8]-Shogaol Related Classifications
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