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  6. (E)-[8]-Shogaol

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(E)-[8]-Shogaol

(E)-[8]-Shogaol Chemical Structure

CAS No. : 104186-07-4

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(E)-[8]-Shogaol Related Antibodies

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In Vitro

(E)-[8]-Shogaol Related Antibodies

Cell Viability Assay[1]

Cell Line: human promyelocytic leukemia HL-60 cells
Concentration: 10, 20, 30, 40, 50 μM
Incubation Time: 24 h
Result: Reduced HL-60 cell viability in a concentration-dependent manner.
Decreased cell viability to ~60% at 10 μM, ~45% at 20 μM, ~5% at 30 μM, and near 0% at 40 and 50 μM.
Showed statistically significant differences from control at all concentrations (P < 0.001).

Apoptosis Analysis[1]

Cell Line: human promyelocytic leukemia HL-60 cells
Concentration: 10, 20, 30, 40, 50 μM (24 h incubation); 30 μM (1, 3, 6, 9, 12 h incubation)
Incubation Time: 24 h (10, 20, 30, 40, 50 μM); 1, 3, 6, 9, 12 h (30 μM)
Result: Increased percentage of apoptotic HL-60 cells (sub-G1 population) to 11.70% at 10 μM, 25.97% at 20 μM, 35.68% at 30 μM, 41.43% at 40 μM, and 43.67% at 50 μM after 24 h treatment.
Increased sub-G1 population to 6.19% at 1 h, 10.42% at 3 h, 31.43% at 6 h, 28.06% at 9 h, and 25.64% at 12 h with 30 μM treatment over time.

Cell Cytotoxicity Assay[2]

Cell Line: human colon cancer HCT116 cells, normal human HEK293 cells
Concentration: 5-40 μM (MTT assay); 15-25 μM (morphological analysis)
Incubation Time: 24 h (MTT assay); null (morphological analysis)
Result: Exhibited a concentration-dependent inhibitory effect on HCT116 cells, with an IC50 value of 20.03 μM.
Showed minimal toxicity towards normal HEK293 cells.
Reduced HCT116 cell number and induced rounded, vacuolated morphology with increasing concentration.

Western Blot Analysis[2]

Cell Line: human colon cancer HCT116 cells
Concentration: 15-25 μM (single treatment); 20 μM (co-treatment with SC79)
Incubation Time: 24 h
Result: Reduced p-AKT and p-PI3K expression in a concentration-dependent manner, while total AKT and PI3K expression remained relatively stable.
Attenuated SC79-induced p-AKT expression when co-treated with SC79.
In Vivo
Animal Model: Balb/c female nude mice (5 weeks old)[2]
Dosage: 20 mg/kg; 40 mg/kg
Administration: p.o.; daily; 14 days
Result: Reduced mean tumor volume to 0.585 cm3 and mean tumor weight to 0.942 g at 20 mg/kg.
Reduced mean tumor volume to 0.317 cm3 and mean tumor weight to 0.548 g at 40 mg/kg.
Induced reduced cell density, apoptotic cells, and necrotic regions in tumor tissue via H&E staining.
Increased apoptosis in a concentration-dependent pattern confirmed by TUNEL staining.
Reduced P-AKT expression and increased Beclin-1 expression in tumor tissue at 40 mg/kg.
Molecular Weight

304.42

Formula

C19H28O3
CAS No.
SMILES

CCCCCCC/C=C/C(CCC1=CC(OC)=C(C=C1)O)=O
Structure Classification
Initial Source
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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(E)-[8]-Shogaol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-[8]-Shogaol104186-07-4Inhibitorinhibitorinhibit

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