(E)-[8]-Shogaol
For research use only. We do not sell to patients.
- CAS No.: 104186-07-4
- Formula: C19H28O3
- Molecular Weight:304.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![(E)-[8]-Shogaol Chemical Structure](https://file.medchemexpress.com/product_pic/hy-n2435a.gif "Click to View (E)-[8]-Shogaol Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | ED50 |
8.8 μM
Compound: 10
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Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay
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[PMID: 14980683] |
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Cell Line:human promyelocytic leukemia HL-60 cells
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Concentration:10, 20, 30, 40, 50 μM
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Incubation Time:24 h
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Result:Reduced HL-60 cell viability in a concentration-dependent manner.
Decreased cell viability to ~60% at 10 μM, ~45% at 20 μM, ~5% at 30 μM, and near 0% at 40 and 50 μM.
Showed statistically significant differences from control at all concentrations (P < 0.001).
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Cell Line:human promyelocytic leukemia HL-60 cells
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Concentration:10, 20, 30, 40, 50 μM (24 h incubation); 30 μM (1, 3, 6, 9, 12 h incubation)
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Incubation Time:24 h (10, 20, 30, 40, 50 μM); 1, 3, 6, 9, 12 h (30 μM)
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Result:Increased percentage of apoptotic HL-60 cells (sub-G1 population) to 11.70% at 10 μM, 25.97% at 20 μM, 35.68% at 30 μM, 41.43% at 40 μM, and 43.67% at 50 μM after 24 h treatment.
Increased sub-G1 population to 6.19% at 1 h, 10.42% at 3 h, 31.43% at 6 h, 28.06% at 9 h, and 25.64% at 12 h with 30 μM treatment over time.
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Cell Line:human colon cancer HCT116 cells, normal human HEK293 cells
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Concentration:5-40 μM (MTT assay); 15-25 μM (morphological analysis)
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Incubation Time:24 h (MTT assay); null (morphological analysis)
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Result:Exhibited a concentration-dependent inhibitory effect on HCT116 cells, with an IC50 value of 20.03 μM.
Showed minimal toxicity towards normal HEK293 cells.
Reduced HCT116 cell number and induced rounded, vacuolated morphology with increasing concentration.
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Cell Line:human colon cancer HCT116 cells
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Concentration:15-25 μM (single treatment); 20 μM (co-treatment with SC79)
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Incubation Time:24 h
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Result:Reduced p-AKT and p-PI3K expression in a concentration-dependent manner, while total AKT and PI3K expression remained relatively stable.
Attenuated SC79-induced p-AKT expression when co-treated with SC79.
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Animal Model:Balb/c female nude mice (5 weeks old)[2]
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Dosage:20 mg/kg; 40 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Reduced mean tumor volume to 0.585 cm3 and mean tumor weight to 0.942 g at 20 mg/kg.
Reduced mean tumor volume to 0.317 cm3 and mean tumor weight to 0.548 g at 40 mg/kg.
Induced reduced cell density, apoptotic cells, and necrotic regions in tumor tissue via H&E staining.
Increased apoptosis in a concentration-dependent pattern confirmed by TUNEL staining.
Reduced P-AKT expression and increased Beclin-1 expression in tumor tissue at 40 mg/kg.
Chemical Information
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CAS No. 104186-07-4
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Molecular Weight 304.42
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Formula C19H28O3
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SMILES
CCCCCCC/C=C/C(CCC1=CC(OC)=C(C=C1)O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E)-[8]-Shogaol Related Classifications
HY-N2435A Related Classifications
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