1. NF-κB
  2. IKK

INH14 

Cat. No.: HY-114454 Purity: >98.0%
Handling Instructions

INH14 is an inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity.

For research use only. We do not sell to patients.

INH14 Chemical Structure

INH14 Chemical Structure

CAS No. : 200134-22-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 176 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg USD 260 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
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100 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

INH14 is an inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity[1].

IC50 & Target[1]

IKKβ

3.59 μM (IC50)

IKKα

8.97 μM (IC50)

In Vivo

INH14 (5 µg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice[1].

Animal Model: 8-week old, male, pathogen-free C57BL/6J mice[1]
Dosage: 5 µg/g, one hour before Pam2CSK4 injection
Administration: I.P. for 2 hours
Result: Decreased TNFα production in mice.
References
Molecular Weight

240.30

Formula

C₁₅H₁₆N₂O

CAS No.

200134-22-1

SMILES

O=C(NC1=CC=CC=C1)NC2=CC=C(CC)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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INH14
Cat. No.:
HY-114454
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INH14

Cat. No.: HY-114454