TAB3 - TGF-beta activated kinase 1 (MAP3K7) binding protein 3 Gene

Also Known as NAP1; MAP3K7IP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 257397

About TAB3

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,827,442-30,889,254 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues.

Summary

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

TAB3 Products (4)

mRNA Protein Name
NM_001399870.1 NP_001386799.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 2
NM_001399872.1 NP_001386801.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 3
NM_001399873.1 NP_001386802.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 4
NM_152787.5 NP_690000.3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
15327770 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
15327770 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17158449 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
22158122 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
18079694 GOA
involved in non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15327770 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15327770 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
23487264 GOA
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15327770 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAB3 Protein Structure

CUE

CUE: CUE domain (11 - 50)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
Protein Preferred Names Protein Names

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

  • NF-kappa-B-activating protein 1

TAB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TAB3 Q8N5C8 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Prey Pooling
25416956
Intra
TAB3 Q8N5C8 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Array
25416956
Intra
TAB3 Q8N5C8 MAP3K7CL Homo sapiens P57077-4
Y2H Prey Pooling
25416956
Intra
TAB3 Q8N5C8 MAP3K7CL Homo sapiens P57077-4
Validated Y2H
25416956
Intra
TAB3 Q8N5C8 MAP3K7CL Homo sapiens P57077-4
Y2H Prey Pooling
32296183
Intra
TAB3 Q8N5C8 MAP3K7CL Homo sapiens P57077-4
Y2H Array
32296183
Intra
TAB3 Q8N5C8 MAP3K7 Homo sapiens O43318
Anti Bait CoIP
22081109
Intra
TAB3 Q8N5C8 MAP3K7 Homo sapiens O43318
Anti Tag CoIP
21903422
Intra
TAB3 Q8N5C8 BECN1 Homo sapiens Q14457
Anti Tag CoIP
22081109
Intra
TAB3 Q8N5C8 BECN1 Homo sapiens Q14457
Anti Bait CoIP
22081109
Cross: Cross-species interaction Intra: Intraspecies interaction

TAB3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82656 TAB3 Antibody (YA2401) WB, ICC/IF Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14135 TAB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19386 Tab3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25878 Tab3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TAB3 VGNC VGNC:47060
Mus musculus TAB3 MGD MGI:1913974
Rattus norvegicus TAB3 RGD RGD:1594527
Bos taurus TAB3 VGNC VGNC:56955
Others TAB3 NCBI