SPOP-IN-2
Based on 1 Customer Validation
SPOP-IN-2 (compound E1) is a Speckle-type POZ protein (SPOP) inhibitor with IC50 of 0.58 μM, which disrupt the SPOP-subtrate interaction and selectively inhibits proliferation of ccRCC.
For research use only. We do not sell to patients.
- Purity: 91.00%
- CAS No.: 3031640-86-2
- Formula: C15H13ClN2O5S
- Molecular Weight:368.79
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
SPOP-IN-2 (0-40 μM) binds to SPOPMATH protein through competition with puc-SBC1 peptide, disrupts the interaction between SPOPMATH and Myc-PTEN or Myc-DUSP7[1].
SPOP-IN-2 (0-50 μM) selectively inhibits the colony formation of ccRCC in cell lines OS-RC-2, 786-O, A498, and 769-P[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:293T
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Concentration:0-40 μM
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Incubation Time:2 h
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Result:Decreased Myc-PTEN and Myc-DUSP7 in a dose-dependent manner.
Chemical Information
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CAS No. 3031640-86-2
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Appearance Solid
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Molecular Weight 368.79
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Formula C15H13ClN2O5S
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Color Light yellow to yellow
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SMILES
O=C1[C@@H](NC(C2=CC=C(CCl)O2)=O)[C@@]3([H])SCC(C=C)=C(C(O)=O)N31
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)