SPOP-IN-1
Based on 1 Customer Validation
SPOP-IN-1 is a selective SPOP E3 ubiquitin ligase inhibitor. SPOP-IN-1 leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.71%
- CAS No.: 2136270-56-7
- 화학식: C26H31N7O2S
- 분자량:505.64
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A498 | IC50 |
2.1 μM
Compound: 6lc
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Antiproliferative activity against human A498 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A498 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32297747] |
| A549 | IC50 |
16.2 μM
Compound: 6lc
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32297747] |
| HK-2 | IC50 |
>30 μM
Compound: 6lc
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Cytotoxicity against human HK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32297747] |
| Hs 766 | IC50 |
14.5 μM
Compound: 6lc
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Cytotoxicity against human Hs766T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human Hs766T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32297747] |
| NCI-H1299 | IC50 |
10.7 μM
Compound: 6lc
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Cytotoxicity against human H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32297747] |
| OS-RC-2 | IC50 |
3.5 μM
Compound: 6lc
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Antiproliferative activity against human OS-RC2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human OS-RC2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32297747] |
| U-251 | IC50 |
10.2 μM
Compound: 6lc
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Cytotoxicity against human U251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 32297747] |
Chemical Information
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CAS No. 2136270-56-7
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Appearance Solid
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분자량 505.64
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화학식 C26H31N7O2S
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Color Light yellow to yellow
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SMILES
O=C(C1=CC2=C(N(CCC3=CC=CS3)C1=N)N=C4C(C)=CC=CN4C2=O)NCCN5CCN(CC5)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 5 mg/mL (9.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9777 mL | 9.8885 mL | 19.7769 mL | 49.4423 mL |
| 5 mM | 0.3955 mL | 1.9777 mL | 3.9554 mL | 9.8885 mL |
SPOP-IN-1 Related Classifications
HY-156382 Related Classifications
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