2. Gene
  3. POLR3C - RNA polymerase III subunit C Gene

POLR3C - RNA polymerase III subunit C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C82; RPC3; RPC62

Gene ID: 10623 | Gene type: protein coding

About POLR3C

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,824,200-145,844,402 (from NCBI)

This gene has 27 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 7.3), lymph node (RPKM 3.9) and 25 other tissues.

Summary

Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]

POLR3C Products(2)

mRNA Protein Name
NM_001303456.1 NP_001290385.1 DNA-directed RNA polymerase III subunit RPC3 isoform 2
NM_006468.8 NP_006459.3 DNA-directed RNA polymerase III subunit RPC3 isoform 1

POLR3C Protein Structure

HTH_9

HTH_9: RNA polymerase III subunit RPC82 helix-turn-helix domain (7 - 67)

RNA_pol_Rpc82

RNA_pol_Rpc82: RNA polymerase III subunit RPC82 (146 - 345)

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  • 534 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase III subunit RPC3

DNA-directed III 62 kDa polypeptide

Related Diseases

Diseases Alias
Petroclival Meningioma
Skull Base Meningioma

Meningioma Of The Skull Base
Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms
Atrial Septal Defect 2

ASD2

Atrial Heart Septal Defect 2

Atrial Septal Defect-2

Asd Ii

Septal Defect, Atrial, Type 2
Chickenpox

Varicella

Varicella Nos
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10857 POLR3C Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus POLR3C VGNC VGNC:64291
Rattus norvegicus POLR3C RGD RGD:1311545
Canis familiaris POLR3C VGNC VGNC:44802
Mus musculus POLR3C MGD MGI:1921664
Macaca mulatta POLR3C VGNC VGNC:76139
Bos taurus POLR3C VGNC VGNC:33147