POLR3C - RNA polymerase III subunit C Gene

Also Known as C82; RPC3; RPC62

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10623

About POLR3C

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,824,200-145,844,402 (from NCBI)

This gene has 27 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 7.3), lymph node (RPKM 3.9) and 25 other tissues.

Summary

Enables single-stranded DNA binding activity. Involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]

POLR3C Products (2)

mRNA Protein Name
NM_001303456.1 NP_001290385.1 DNA-directed RNA polymerase III subunit RPC3 isoform 2
NM_006468.8 NP_006459.3 DNA-directed RNA polymerase III subunit RPC3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11416169 GOA
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
21358628 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
19609254 GOA
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
19609254 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase III complex IDA
IDA: Inferred from direct assay
24107381 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR3C Protein Structure

HTH_9

HTH_9: RNA polymerase III subunit RPC82 helix-turn-helix domain (7 - 67)

RNA_pol_Rpc82

RNA_pol_Rpc82: RNA polymerase III subunit RPC82 (146 - 345)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase III subunit RPC3

  • DNA-directed III 62 kDa polypeptide

POLR3C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POLR3C Q9BUI4 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
25416956
Intra
POLR3C Q9BUI4 PNMA5 Homo sapiens Q96PV4
Validated Y2H
25416956
Intra
POLR3C Q9BUI4 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
Intra
POLR3C Q9BUI4 TNR Homo sapiens A1L306
Y2H Prey Pooling
25416956
Intra
POLR3C Q9BUI4 TNR Homo sapiens A1L306
Y2H Array
25416956
Intra
POLR3C Q9BUI4 NCKIPSD Homo sapiens Q9NZQ3-3
Validated Y2H
32296183
Intra
POLR3C Q9BUI4 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Array
32296183
Intra
POLR3C Q9BUI4 RBBP8NL Homo sapiens Q8NC74
Y2H Array
32296183
Intra
POLR3C Q9BUI4 RBBP8NL Homo sapiens Q8NC74
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
Intra
POLR3C Q9BUI4 CAMK2B Homo sapiens Q13554-3
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 CAMK2B Homo sapiens Q13554-3
Y2H Array
32296183
Intra
POLR3C Q9BUI4 UBXN1 Homo sapiens Q04323-2
Y2H Array
32296183
Intra
POLR3C Q9BUI4 UBXN1 Homo sapiens Q04323-2
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
POLR3C Q9BUI4 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
POLR3C Q9BUI4 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
POLR3C Q9BUI4 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
POLR3C Q9BUI4 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
POLR3C Q9BUI4 VAX1 Homo sapiens Q5SQQ9-2
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 VAX1 Homo sapiens Q5SQQ9-2
Y2H Array
32296183
Intra
POLR3C Q9BUI4 POLR3G Homo sapiens O15318
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 POLR3G Homo sapiens O15318
Anti Tag CoIP
35271311
Intra
POLR3C Q9BUI4 POLR3G Homo sapiens O15318
Y2H
21358628
Intra
POLR3C Q9BUI4 POLR3G Homo sapiens O15318
Y2H Array
32296183
Intra
POLR3C Q9BUI4 VRTN Homo sapiens Q9H8Y1
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 VRTN Homo sapiens Q9H8Y1
Validated Y2H
32296183
Intra
POLR3C Q9BUI4 VRTN Homo sapiens Q9H8Y1
Y2H Array
32296183
Intra
POLR3C Q9BUI4 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
25416956
Intra
POLR3C Q9BUI4 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 HAUS1 Homo sapiens Q96CS2
Y2H Array
32296183
Intra
POLR3C Q9BUI4 POLR3GL Homo sapiens Q9BT43
Y2H
21358628
Intra
POLR3C Q9BUI4 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
POLR3C Q9BUI4 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
POLR3C Q9BUI4 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 KPNA3 Homo sapiens O00505
Y2H Array
32296183
Intra
POLR3C Q9BUI4 KPNA1 Homo sapiens P52294
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 KPNA1 Homo sapiens P52294
Y2H Array
32296183
Intra
POLR3C Q9BUI4 KPNA6 Homo sapiens O60684
Y2H Array
32296183
Intra
POLR3C Q9BUI4 KPNA6 Homo sapiens O60684
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra
POLR3C Q9BUI4 ANKRD23 Homo sapiens Q86SG2
Y2H Array
32296183
Intra
POLR3C Q9BUI4 ANKRD23 Homo sapiens Q86SG2
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
POLR3C Q9BUI4 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
POLR3C Q9BUI4 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 SP100 Homo sapiens P23497-2
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 SP100 Homo sapiens P23497-2
Y2H Array
32296183
Intra
POLR3C Q9BUI4 POLR3F Homo sapiens Q9H1D9
Anti Tag CoIP
35271311
Intra
POLR3C Q9BUI4 POLR3F Homo sapiens Q9H1D9
Pull Down
21358628
Intra
POLR3C Q9BUI4 KATNBL1 Homo sapiens Q9H079
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 KATNBL1 Homo sapiens Q9H079
Validated Y2H
32296183
Intra
POLR3C Q9BUI4 KATNBL1 Homo sapiens Q9H079
Y2H Array
32296183
Intra
POLR3C Q9BUI4 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
POLR3C Q9BUI4 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
POLR3C Q9BUI4 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
POLR3C Q9BUI4 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 KIAA0408 Homo sapiens Q6ZU52
MAPPIT
32296183
Intra
POLR3C Q9BUI4 KIAA0408 Homo sapiens Q6ZU52
Y2H Array
32296183
Intra
POLR3C Q9BUI4 KIAA0408 Homo sapiens Q6ZU52
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
POLR3C Q9BUI4 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 ENKD1 Homo sapiens Q9H0I2
Y2H Array
32296183
Intra
POLR3C Q9BUI4 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 CEP44 Homo sapiens Q9C0F1
Validated Y2H
32296183
Intra
POLR3C Q9BUI4 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Intra
POLR3C Q9BUI4 KLHL2 Homo sapiens O95198
Y2H Array
32296183
Intra
POLR3C Q9BUI4 KLHL2 Homo sapiens O95198
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
POLR3C Q9BUI4 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
POLR3C Q9BUI4 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
POLR3C Q9BUI4 ROCK1 Homo sapiens Q13464
Y2H Prey Pooling
25416956
Intra
POLR3C Q9BUI4 ROCK1 Homo sapiens Q13464
Validated Y2H
25416956
Intra
POLR3C Q9BUI4 COIL Homo sapiens P38432
Y2H Prey Pooling
32296183
Intra
POLR3C Q9BUI4 COIL Homo sapiens P38432
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Petroclival Meningioma
Skull Base Meningioma

  • Meningioma Of The Skull Base
Skull Base Cancer

  • Tumors Of Skull Base

  • Skull Base Neoplasms
Atrial Septal Defect 2

  • ASD2

  • Atrial Heart Septal Defect 2

  • Atrial Septal Defect-2

  • Asd Ii

  • Septal Defect, Atrial, Type 2
Chickenpox

  • Varicella

  • Varicella Nos
Hypomyelinating Leukodystrophy

  • Hld

  • Leukodystrophy, Hypomyelinating
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10857 POLR3C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus POLR3C VGNC VGNC:64291
Rattus norvegicus POLR3C RGD RGD:1311545
Canis familiaris POLR3C VGNC VGNC:44802
Mus musculus POLR3C MGD MGI:1921664
Macaca mulatta POLR3C VGNC VGNC:76139
Bos taurus POLR3C VGNC VGNC:33147
Others POLR3C NCBI