DCPS - decapping enzyme, scavenger Gene

Also Known as ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 28960

About DCPS

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,304,060-126,350,005 (from NCBI)

This gene has 4 transcripts (splice variants), 211 orthologues and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 6.1), gall bladder (RPKM 5.3) and 25 other tissues.

Summary

This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of Other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and MicroRNA turnover. [provided by RefSeq, Apr 2017]

DCPS Products (2)

mRNA Protein Name
NM_001350236.2 NP_001337165.1 m7GpppX diphosphatase isoform 1
NM_014026.6 NP_054745.1 m7GpppX diphosphatase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity IDA
IDA: Inferred from direct assay
12198172 GOA
enables RNA 7-methylguanosine cap binding IDA
IDA: Inferred from direct assay
12198172 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16140270 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA cis splicing, via spliceosome IDA
IDA: Inferred from direct assay
18426921 GOA
involved in mRNA methylguanosine-cap decapping IDA
IDA: Inferred from direct assay
26049109 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18441014 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12871939 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCPS Protein Structure

DcpS

DcpS: Scavenger mRNA decapping enzyme (DcpS) N-terminal (44 - 146)

DcpS_C

DcpS_C: Scavenger mRNA decapping enzyme C-term binding (174 - 291)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

m7GpppX diphosphatase

  • 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

DCPS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DCPS Q96C86 KPNA2 Homo sapiens P52292
Y2H Array
32296183
Intra
DCPS Q96C86 KPNA2 Homo sapiens P52292
Y2H Prey Pooling
32296183
Intra
DCPS Q96C86 KPNA6 Homo sapiens O60684
Y2H Prey Pooling
32296183
Intra
DCPS Q96C86 KPNA6 Homo sapiens O60684
Y2H Array
32296183
Intra
DCPS Q96C86 DCPS Homo sapiens Q96C86
Y2H Prey Pooling
32296183
Intra
DCPS Q96C86 DCPS Homo sapiens Q96C86
Validated Y2H
32296183
Intra
DCPS Q96C86 CHST4 Homo sapiens Q8NCG5
Y2H Array
21988832
Intra
DCPS Q96C86 DCPS Homo sapiens Q96C86
Y2H Array
32296183
Intra
DCPS Q96C86 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra
DCPS Q96C86 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra
DCPS Q96C86 SSRP1 Homo sapiens Q08945
Crosslink
30021884
Intra
DCPS Q96C86 GPC5 Homo sapiens P78333
Y2H Array
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Al-Raqad Syndrome

  • ARS
Autosomal Recessive Non-Syndromic Intellectual Disability

  • Ar-Nsid

  • Ns-Arid
Muscular Atrophy

  • Muscle Wasting

  • Amyotrophia

  • Wasting - Muscle

  • Skeletal Muscle Atrophy
Spinal Muscular Atrophy, Type I

  • Werdnig-Hoffmann Disease

  • SMA1

  • Spinal Muscular Atrophy 1

  • Sma I

  • Sma, Infantile Acute Form

  • Muscular Atrophy, Infantile

  • Spinal Muscular Atrophy-1

  • Hmn Proximal Type I

  • Infantile Muscular Atrophy

  • Proximal Spinal Muscular Atrophy Type 1

  • Sma Type 1

  • Sma Type I

  • Sma-I

  • Hereditary Motor Neuropathy Proximal Type I

  • Progressive Muscular Atrophy Of Infancy

  • Proximal Spinal Muscular Atrophy, Type 1

  • Werdnig Hoffmann Disease

  • Infantile Spinal Muscular Atrophy

  • Infantile-Onset Spinal Muscular Atrophy

  • Proximal Hereditary Motor Neuropathy Type I

  • Sma Infantile Acute Form

  • Spinal Muscular Atrophy Type I

  • Werdnig-Hoffman Disease

  • Atrophy, Muscular, Spinal, Type 1
Spinal Muscular Atrophy, Type Iii

  • SMA3

  • Juvenile Spinal Muscular Atrophy

  • Kugelberg-Welander Disease

  • Sma Iii

  • Kugelberg-Welander Syndrome

  • Kws

  • Muscular Atrophy, Juvenile

  • Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy-3

  • Spinal Muscular Atrophy Type 3

  • Spinal Muscular Atrophy, Type Iii, Modifier Of

  • Type Iii Spinal Muscular Atrophy

  • Sma 3

  • Proximal Spinal Muscular Atrophy Type 3

  • Sma Type 3

  • Sma Type Iii

  • Sma-Iii

  • Spinal Muscular Atrophy 3

  • Spinal Muscular Atrophy Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy Type Iii

  • Wohlfart-Kugelberg-Welander Disease

  • Atrophy, Muscular, Spinal, Type Iii
Childhood Spinal Muscular Atrophy

  • Spinal Muscular Atrophies Of Childhood

  • Survival Motor Neuron Spinal Muscular Atrophy
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-102020 RG3039 99.30% Phase 1
HY-122604 PF-DcpSi 98.0% Phase 1
HY-102020R RG3039 (Standard) / Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108599 DCP-LA 98.0% Unkown
HY-145969A β-S-ARCA triammonium 99.48% Unkown
HY-W087905 2,3-Dimethyl-2,3-diphenylbutane 98.79% Unkown
HY-102020A RG3039 hydrochloride 98.15% Unkown
HY-131933 DCP-Bio3 98.10% Unkown
HY-145969 β-S-ARCA / Unkown
HY-164977 JCS-1 Inhibitor 99.38% Unkown
HY-RS03584 DCP1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-178672A ARCA triammonium solution (100 mM) / Unkown
HY-138147 DCP-Rho1 / Unkown
HY-155771 1-DCP / Unkown
HY-RS03585 DCP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03586 DCP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03587 DCPS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-D3473 DCP-Bio1 / Unkown
HY-RS20712 Dcps Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27223 Dcps Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DCPS RGD RGD:628887
Mus musculus DCPS MGD MGI:1916555
Macaca mulatta DCPS VGNC VGNC:71816
Felis catus DCPS VGNC VGNC:61375
Canis familiaris DCPS VGNC VGNC:39811
Bos taurus DCPS VGNC VGNC:27922
Others DCPS NCBI