JCS-1
Based on 1 Customer Validation
JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3
ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC50 in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders.
(Pink: DcpS ligand (HY-102020); Blue: VHL ligand (HY-151227); Black: linker (HY-141230)).
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 3093519-24-2
- Formula: C62H79N9O12S
- Molecular Weight:1174.41
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
|
VHL |
JCS-1 (0.1-10000 nM, 24 h) degrades DcpS in MOLM-14 cells in a dose-dependent manner with a DC50 of 87 nM[1].
JCS-1 (1 μM) degrades DcpS rapidly and continuously in MOLM-14 cells, with degradation occurring rapidly within 2 h of treatment and maximum degradation occurring between 12 and 24 h[1].
JCS-1 (1 μM, every 3 days for 12 days) inhibits the proliferation and viability of MOLM-14 cells with an IC50 value of 1.1 μM[1].
JCS-1 (1 μM, 6 h) influences the mRNA pool of MOLM-14 cells with significant increase in SNORD99 and DDX24 expression[1].
Degradation by JCS-1 is inhibited by the neddylation inhibitor MLN4924 (HY-70062) and proteasome inhibitor Epoxomicin (HY-13821) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3093519-24-2
-
Appearance Solid
-
Molecular Weight 1174.41
-
Formula C62H79N9O12S
-
Color White to off-white
-
SMILES
O=C([C@H]1N(C([C@@H](N(CC2=C3C=CC=C2)C3=O)C(C)C)=O)C[C@H](O)C1)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCCOCCOCCOCCOCCOCCOC6=CC=CC(CN7CCC(COC8=CC=CC9=NC(N)=NC(N)=C89)CC7)=C6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (85.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (268 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8515 mL | 4.2575 mL | 8.5149 mL | 21.2873 mL |
| 5 mM | 0.1703 mL | 0.8515 mL | 1.7030 mL | 4.2575 mL | |
| 10 mM | 0.0851 mL | 0.4257 mL | 0.8515 mL | 2.1287 mL | |
| 15 mM | 0.0568 mL | 0.2838 mL | 0.5677 mL | 1.4192 mL | |
| 20 mM | 0.0426 mL | 0.2129 mL | 0.4257 mL | 1.0644 mL | |
| 25 mM | 0.0341 mL | 0.1703 mL | 0.3406 mL | 0.8515 mL | |
| 30 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.7096 mL | |
| 40 mM | 0.0213 mL | 0.1064 mL | 0.2129 mL | 0.5322 mL | |
| 50 mM | 0.0170 mL | 0.0851 mL | 0.1703 mL | 0.4257 mL | |
| 60 mM | 0.0142 mL | 0.0710 mL | 0.1419 mL | 0.3548 mL | |
| 80 mM | 0.0106 mL | 0.0532 mL | 0.1064 mL | 0.2661 mL |
JCS-1 Related Classifications
HY-164977 Related Classifications
Powered by Bioz