1. Metabolic Enzyme/Protease
  2. Proteasome

Epoxomicin (Synonyms: BU-4061T)

Cat. No.: HY-13821 Purity: 99.89%
Handling Instructions

Epoxomicin(BU-4061T) is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.

For research use only. We do not sell to patients.

Epoxomicin Chemical Structure

Epoxomicin Chemical Structure

CAS No. : 134381-21-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 586 In-stock
Estimated Time of Arrival: December 31
100 μg USD 96 In-stock
Estimated Time of Arrival: December 31
1 mg USD 156 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 840 In-stock
Estimated Time of Arrival: December 31
20 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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    Epoxomicin purchased from MCE. Usage Cited in: Mol Plant Pathol. 2018 Jul 26.

    Destabilization of BRC1 mediated by SWP1 is inhibited by proteasome inhibitors Epoxomicin and MG132.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Epoxomicin(BU-4061T) is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. IC50 value: Target: 20S proteasome in vitro: Epoxomicin inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM [1] [2]. By inhibiting osteoblast proteasome activity, epoxomicin stimulates bone formation at concentrations as low as 10 nM [3]. in vivo: Intraperitoneal injection of 1.5 mg/kg epoxomicin given daily for two weeks induces Parkinson’s-like symptoms in rats and addition of 100 nM epoxomicin to rat ventral midbrain cultures results in apoptosis specific to dopaminergic neurons [4].

    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8027 mL 9.0136 mL 18.0271 mL
    5 mM 0.3605 mL 1.8027 mL 3.6054 mL
    10 mM 0.1803 mL 0.9014 mL 1.8027 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    554.72

    Formula

    C₂₈H₅₀N₄O₇

    CAS No.

    134381-21-8

    SMILES

    O=C([[email protected]@H](NC([[email protected]]([[email protected]@H](C)O)NC([[email protected]@H](NC([[email protected]]([[email protected]@H](C)CC)N(C)C(C)=O)=O)[[email protected]@H](C)CC)=O)=O)CC(C)C)[[email protected]@]1(C)CO1

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.89%

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    Product Name:
    Epoxomicin
    Cat. No.:
    HY-13821
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    Epoxomicin

    Cat. No.: HY-13821