1. Metabolic Enzyme/Protease
  2. Proteasome

Epoxomicin (Synonyms: BU-4061T)

Cat. No.: HY-13821 Purity: 99.89%
Data Sheet SDS Handling Instructions

Epoxomicin(BU-4061T) is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.

For research use only. We do not sell to patients.
Epoxomicin Chemical Structure

Epoxomicin Chemical Structure

CAS No. : 134381-21-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $488 In-stock
100 ug $80 In-stock
1 mg $130 In-stock
5 mg $400 In-stock
10 mg $700 In-stock
20 mg $1100 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Epoxomicin(BU-4061T) is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. IC50 value: Target: 20S proteasome in vitro: Epoxomicin inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM [1] [2]. By inhibiting osteoblast proteasome activity, epoxomicin stimulates bone formation at concentrations as low as 10 nM [3]. in vivo: Intraperitoneal injection of 1.5 mg/kg epoxomicin given daily for two weeks induces Parkinson’s-like symptoms in rats and addition of 100 nM epoxomicin to rat ventral midbrain cultures results in apoptosis specific to dopaminergic neurons [4].

References
Molecular Weight

554.72

Formula

C₂₈H₅₀N₄O₇

CAS No.

134381-21-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.89%

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Epoxomicin
Cat. No.:
HY-13821
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