1. Metabolic Enzyme/Protease
  2. Proteasome
  3. Epoxomicin

Epoxomicin (Synonyms: BU-4061T)

Cat. No.: HY-13821 Purity: 99.89%
Handling Instructions

Epoxomicin is a cell-permeable and irreversible proteasome inhibitor, primarily the chymotrypsin-like activity.

For research use only. We do not sell to patients.

Epoxomicin Chemical Structure

Epoxomicin Chemical Structure

CAS No. : 134381-21-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 586 In-stock
Estimated Time of Arrival: December 31
100 μg USD 96 In-stock
Estimated Time of Arrival: December 31
1 mg USD 156 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 840 In-stock
Estimated Time of Arrival: December 31
20 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Epoxomicin

    Epoxomicin purchased from MCE. Usage Cited in: Mol Plant Pathol. 2018 Dec;19(12):2623-2634.

    Destabilization of BRC1 mediated by SWP1 is inhibited by proteasome inhibitors Epoxomicin and MG132.
    • Biological Activity

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    Description

    Epoxomicin is a cell-permeable and irreversible proteasome inhibitor, primarily the chymotrypsin-like activity.

    Molecular Weight

    554.72

    Formula

    C₂₈H₅₀N₄O₇

    CAS No.

    134381-21-8

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (180.27 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8027 mL 9.0136 mL 18.0271 mL
    5 mM 0.3605 mL 1.8027 mL 3.6054 mL
    10 mM 0.1803 mL 0.9014 mL 1.8027 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.51 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.51 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.51 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Epoxomicin
    Cat. No.:
    HY-13821
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