1. Metabolic Enzyme/Protease
  2. Proteasome
  3. Lactacystin

Lactacystin 

Cat. No.: HY-16594 Purity: ≥98.0%
Handling Instructions

Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces neurite outgrowth.

For research use only. We do not sell to patients.

Lactacystin Chemical Structure

Lactacystin Chemical Structure

CAS No. : 133343-34-7

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500 μg USD 650 In-stock
Estimated Time of Arrival: December 31
1 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A[1]. Lactacystin inhibits cell growth and induces neurite outgrowth[2].

IC50 & Target

IC50: 4.8 μM (proteasome)[1]

In Vivo

Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old[2]
Dosage: 2 µg
Administration: Microinjection
Result: Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.
Molecular Weight

376.43

Formula

C₁₅H₂₄N₂O₇S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥98.0%

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Product Name:
Lactacystin
Cat. No.:
HY-16594
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