1. Metabolic Enzyme/Protease
  2. Proteasome
  3. Lactacystin

Lactacystin 

Cat. No.: HY-16594
Handling Instructions

Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces neurite outgrowth.

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Lactacystin Chemical Structure

Lactacystin Chemical Structure

CAS No. : 133343-34-7

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Description

Lactacystin, an antibiotic Streptomyces spp. metabolite, is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome. Lactacystin also inhibits the lysosomal enzyme cathepsin A[1]. Lactacystin inhibits cell growth and induces neurite outgrowth[2].

IC50 & Target

IC50: 4.8 μM (proteasome)[1]

In Vivo

Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice[2].

Animal Model: Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old[2]
Dosage: 2 µg
Administration: Microinjection
Result: Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.
Molecular Weight

376.43

Formula

C₁₅H₂₄N₂O₇S

CAS No.

133343-34-7

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Lactacystin
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