1. Metabolic Enzyme/Protease
  2. Proteasome

ONX-0914 (Synonyms: PR-957)

Cat. No.: HY-13207 Purity: 98.16%
Handling Instructions

ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome.

For research use only. We do not sell to patients.
ONX-0914 Chemical Structure

ONX-0914 Chemical Structure

CAS No. : 960374-59-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
5 mg USD 60 In-stock
10 mg USD 90 In-stock
50 mg USD 270 In-stock
100 mg USD 450 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome. IC50 Value: ~10 nM [1] in vitro: PR-957 blocked presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo. Selective inhibition of LMP7 by PR-957 blocked production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells [1]. in vivo: In mouse models of rheumatoid arthritis and lupus, ONX-0914 treatment reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels at well-tolerated doses. The maximum tolerated dose (MTD) of ONX-0914 in mice to be 30 mg/kg body weight. IFN-g release is inhibited by ~60% at LMP7-selective concentrations of ONX-0914 and by ~90% at higher concentrations. Production of IL-2 is also inhibited by ~50% [1].

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7221 mL 8.6107 mL 17.2215 mL
5 mM 0.3444 mL 1.7221 mL 3.4443 mL
10 mM 0.1722 mL 0.8611 mL 1.7221 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







O=C(N[[email protected]@H](C)C(N[[email protected]@H](CC1=CC=C(OC)C=C1)C(N[[email protected]@H](CC2=CC=CC=C2)C([[email protected]]3(C)OC3)=O)=O)=O)CN4CCOCC4

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 35 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.16%

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