Epoxomicin, a new antitumor agent of microbial origin

  • J Antibiot (Tokyo). 1992 Nov;45(11):1746-52. doi: 10.7164/antibiotics.45.1746.
M Hanada  1 ,  K Sugawara ,  K Kaneta ,  S Toda ,  Y Nishiyama ,  K Tomita ,  H Yamamoto ,  M Konishi ,  T Oki
Affiliations
  • 1. Bristol-Myers Squibb Research Institute, Tokyo, Japan.
PMID: 1468981 DOI: 10.7164/antibiotics.45.1746
Abstract

An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-beta-aminoketone group, and is closely related to eponemycin.

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