3093519-24-2
Chemical Structure
JCS-1
- CAS No.: 3093519-24-2
- Formula:C62H79N9O12S
- Molecular Weight:1174.41
InChIKey: YDPSDENQMOVTAZ-YVTSNPQKSA-N
SMILES: O=C([C@H]1N(C([C@@H](N(CC2=C3C=CC=C2)C3=O)C(C)C)=O)C[C@H](O)C1)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCCOCCOCCOCCOCCOCCOC6=CC=CC(CN7CCC(COC8=CC=CC9=NC(N)=NC(N)=C89)CC7)=C6
Biological Activity: JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC50 in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JCS-1 | 99.38% | JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC50 in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders. | ||||||||||||||||||||
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Keywords
