ZNF326 - zinc finger protein 326 Gene

Also Known as ZIRD; ZAN75; Zfp326; dJ871E2.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 284695

About ZNF326

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,995,110-90,035,533 (from NCBI)

This gene has 4 transcripts (splice variants), 147 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 6.2), endometrium (RPKM 3.4) and 25 other tissues.

Summary

Enables RNA polymerase II complex binding activity. Involved in regulation of DNA-templated transcription, elongation and regulation of RNA splicing. Located in nucleoplasm. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]

ZNF326 Products (4)

mRNA Protein Name
NM_001320185.2 NP_001307114.1 DBIRD complex subunit ZNF326 isoform 4
NM_181781.4 NP_861446.2 DBIRD complex subunit ZNF326 isoform 2
NM_182975.4 NP_892020.1 DBIRD complex subunit ZNF326 isoform 3
NM_182976.4 NP_892021.1 DBIRD complex subunit ZNF326 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II complex binding IDA
IDA: Inferred from direct assay
22446626 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22446626 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of DNA-templated transcription elongation IMP
IMP: Inferred from mutant phenotype
22446626 GOA
involved in regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
22446626 GOA
Cellular Component GO Annotation Evidence References Source
part of DBIRD complex IDA
IDA: Inferred from direct assay
22446626 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF326 Protein Structure

AKAP95

AKAP95: A-kinase anchoring protein 95 (AKAP95) (312 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

DBIRD complex subunit ZNF326

  • ZNF-protein interacting with nuclear mRNPs and DBC1

ZNF326 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF326 Q5BKZ1 VMAC Homo sapiens Q2NL98
Y2H Array
32296183
Intra
ZNF326 Q5BKZ1 VMAC Homo sapiens Q2NL98
Y2H Prey Pooling
32296183
Intra
ZNF326 Q5BKZ1 GEMIN4 Homo sapiens P57678
Y2H Prey Pooling
32296183
Intra
ZNF326 Q5BKZ1 GEMIN4 Homo sapiens P57678
Y2H Array
32296183
Intra
ZNF326 Q5BKZ1 SPTA1 Homo sapiens P02549
Y2H Array
32296183
Intra
ZNF326 Q5BKZ1 SPTA1 Homo sapiens P02549
Y2H Prey Pooling
32296183
Intra
ZNF326 Q5BKZ1 BRINP1 Homo sapiens O60477
Anti Bait CoIP
22446626
Intra
ZNF326 Q5BKZ1 BRINP1 Homo sapiens O60477
Anti Tag CoIP
22446626
Intra
ZNF326 Q5BKZ1 BRINP1 Homo sapiens O60477
GMS
22446626
Intra
ZNF326 Q5BKZ1 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra
ZNF326 Q5BKZ1 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra
ZNF326 Q5BKZ1 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra
ZNF326 Q5BKZ1 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lenz-Majewski Hyperostotic Dwarfism

  • Lenz-Majewski Syndrome

  • Lenz Majewski Hyperostotic Dwarfism

  • LMHD

  • Hyperostotic Dwarfism Lenz-Majewski Type

  • Lenz-Majewski Hyperostotic Dysplasia

  • Multiple Congenital Anomalies, Intellectual Disability And Progressive Skeletal Sclerosis

  • Lms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16125 ZNF326 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZNF326 VGNC VGNC:67290
Canis familiaris ZNF326 VGNC VGNC:48699
Bos taurus ZNF326 VGNC VGNC:37248
Rattus norvegicus ZNF326 RGD RGD:1592829
Macaca mulatta ZNF326 VGNC VGNC:78945
Mus musculus ZNF326 MGD MGI:1927246
Others ZNF326 NCBI