BRINP1 - BMP/retinoic acid inducible neural specific 1 Gene

Also Known as DBC1; FAM5A; DBCCR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1620

About BRINP1

Cytogenetic location: 9q33.1 Genomic coordinates (GRCh38): 9:119,166,629-119,369,435 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 2 paralogues. Biased expression in brain (RPKM 23.7) and adrenal (RPKM 2.3).

Summary

This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008]

BRINP1 Products (1)

mRNA Protein Name
NM_014618.3 NP_055433.2 BMP/retinoic acid-inducible neural-specific protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12442002 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell cycle IDA
IDA: Inferred from direct assay
11420708 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11420708 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRINP1 Protein Structure

MACPF

MACPF: MAC/Perforin domain (48 - 159)

  • 0
  • 200
  • 400
  • 600
  • 761 a.a.
Protein Preferred Names Protein Names

BMP/retinoic acid-inducible neural-specific protein 1

  • bA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A))

BRINP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BRINP1 O60477 ZNF326 Homo sapiens Q5BKZ1
GMS
22446626
Cross: Cross-species interaction Intra: Intraspecies interaction

BRINP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82685 DISC1 Antibody (YA2430) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Transitional Cell Carcinoma

  • Transitional Cell Neoplasm

  • Carcinoma, Transitional Cell

  • Transitional Carcinoma

  • Transitional Cell Tumor

  • Urothelial Cell Carcinoma

  • Carcinoma Transitional Cell

  • Transitional Cell Carcinoma Of Bladder
Gallbladder Sarcoma

  • Malignant Mesenchymal Tumor Of Gallbladder
Papillary Transitional Carcinoma

  • Papillary Transitional Cell Carcinoma
Non-Invasive Bladder Papillary Urothelial Neoplasm

  • Bladder Papillary Neoplasm Of Low Malignant Potential

  • Bladder Punlmp

  • Papillary Urothelial Neoplasm Of Low Malignant Potential

  • Papillary Transitional Cell Neoplasm Of Low Malignant Potential
Bladder Papillary Transitional Cell Neoplasm

  • Urinary Bladder Papillary Urothelial Neoplasm

  • Bladder Papillary Urothelial Neoplasm
Urinary Tract Papillary Transitional Cell Benign Neoplasm

  • Inverted Papilloma Of Urinary Tract

  • Papillary Transitional Cell Neoplasm Of The Urinary Tract

  • Urinary Tract Inverted Papilloma

  • Inverted Urothelial Papilloma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01620 BRINP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21828 Brinp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BRINP1 RGD RGD:708519
Macaca mulatta BRINP1 VGNC VGNC:104880
Felis catus BRINP1 VGNC VGNC:102903
Canis familiaris BRINP1 VGNC VGNC:38527
Mus musculus BRINP1 MGD MGI:1928478
Bos taurus BRINP1 VGNC VGNC:26567
Others BRINP1 NCBI