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SRSF7 - serine and arginine rich splicing factor 7 Gene

Also Known as 9G8; AAG3; SFRS7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6432

About SRSF7

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,743,599-38,751,494 (from NCBI)

This gene has 12 transcripts (splice variants), 232 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 57.8), lymph node (RPKM 43.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]

SRSF7 Products (3)

mRNA	Protein	Name
NM_001031684.3	NP_001026854.1	serine/arginine-rich splicing factor 7 isoform 1
NM_001195446.2	NP_001182375.1	serine/arginine-rich splicing factor 7 isoform 2
NM_001363802.1	NP_001350731.1	serine/arginine-rich splicing factor 7 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10749975	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10749975	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA splicing	IDA IDA: Inferred from direct assay	8013463	GOA
involved in negative regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15009664	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF7 Protein Structure

RRM_1

0
100
200
238 a.a.

Protein Preferred Names	Protein Names
serine/arginine-rich splicing factor 7	SR splicing factor 7

SRSF7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRSF7	Q16629	RBBP6	Homo sapiens	Q7Z6E9	Anti Tag CoIP	33961781
Intra	SRSF7	Q16629	RBBP6	Homo sapiens	Q7Z6E9	Anti Tag CoIP	18624398
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	31515488
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Y2H Prey Pooling	25416956
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	25416956
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	32296183
Intra	SRSF7	Q16629	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	25416956
Intra	SRSF7	Q16629	RNPS1	Homo sapiens	Q15287	Anti Tag CoIP	33961781
Intra	SRSF7	Q16629	NXF1	Homo sapiens	Q9UBU9	Pull Down	17036044
Intra	SRSF7	Q16629	NXF1	Homo sapiens	Q9UBU9	CoIP	15184380
Intra	SRSF7	Q16629	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	SRSF7	Q16629	SRPK1	Homo sapiens	Q96SB4	Protein Kinase Assay	23602568
Intra	SRSF7	Q16629	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	SRSF7	Q16629	LUC7L	Homo sapiens	Q9NQ29-3	Validated Y2H	32296183
Intra	SRSF7	Q16629	PRPF38A	Homo sapiens	Q8NAV1	Validated Y2H	32296183
Intra	SRSF7	Q16629	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	SRSF7	Q16629	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Cross	SRSF7	Q16629	Srek1	Rattus norvegicus	Q9JKL7	Pull Down	14559993

Cross: Cross-species interaction Intra: Intraspecies interaction

SRSF7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811025	SRSF7 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Allergic Bronchopulmonary Aspergillosis	Aspergillosis, Allergic Bronchopulmonary Abpa Allergic Bronchopulmonary Mycosis Hinson-Pepys Disease Pulmonary Aspergillus Disease Allergic Aspergillosis Aspergillosis Allergic Bronchopulmonary
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13798	SRSF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19484	Srsf7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25977	Srsf7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRSF7	VGNC	VGNC:77822
Felis catus	SRSF7	VGNC	VGNC:81226
Canis familiaris	SRSF7	VGNC	VGNC:46821
Rattus norvegicus	SRSF7	RGD	RGD:1307425
Mus musculus	SRSF7	MGD	MGI:1926232
Bos taurus	SRSF7	VGNC	VGNC:35303
Others	SRSF7	NCBI