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RBBP6 - RB binding protein 6, ubiquitin ligase Gene

Also Known as PACT; MY038; P2P-R; RBQ-1; SNAMA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5930

About RBBP6

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:24,539,566-24,572,863 (from NCBI)

This gene has 14 transcripts (splice variants), 150 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 15.6), testis (RPKM 14.0) and 25 other tissues.

Summary

The retinoblastoma tumor suppressor (pRB) protein binds with many Other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RBBP6 Products (3)

mRNA	Protein	Name
NM_006910.5	NP_008841.2	E3 ubiquitin-protein ligase RBBP6 isoform 1
NM_018703.4	NP_061173.1	E3 ubiquitin-protein ligase RBBP6 isoform 2
NM_032626.6	NP_116015.2	E3 ubiquitin-protein ligase RBBP6 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18624398	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20873783	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	24726359	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	18851979	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	24726359	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	24726359	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	18851979	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24726359	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBBP6 Protein Structure

DWNN

zf-CCHC

zf-C3HC4_2

0
300
600
900
1200
1500
1792 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RBBP6	RB-binding Q-protein 1

RBBP6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBBP6	Q7Z6E9	SRSF7	Homo sapiens	Q16629	Confocal	18624398
Intra	RBBP6	Q7Z6E9	SRSF7	Homo sapiens	Q16629	Y2H	18624398

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Type 1 Diabetes Mellitus 20	Diabetes Mellitus, Insulin-Dependent, 20 IDDM20 T1D20 Insulin-Dependent Diabetes Mellitus 20 Diabetes Mellitus, Insulin-Dependent, Type 20
Leber Congenital Amaurosis 1	LCA1 Amaurosis Congenita Of Leber I Lca Retinal Blindness, Congenital Crb Leber Congenital Amaurosis Type I Leber Congenital Amaurosis, Type 1 Amaurosis Congenita Of Leber, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11718	RBBP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21722	Rbbp6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28240	Rbbp6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RBBP6	VGNC	VGNC:107813
Rattus norvegicus	RBBP6	RGD	RGD:1311964
Mus musculus	RBBP6	MGD	MGI:894835
Bos taurus	RBBP6	VGNC	VGNC:33771
Macaca mulatta	RBBP6	VGNC	VGNC:76677
Canis familiaris	RBBP6	VGNC	VGNC:45392
Others	RBBP6	NCBI