LUC7L2 - LUC7 like 2, pre-mRNA splicing factor Gene
Also Known as CGI-59; CGI-74; LUC7B2
Species: Homo sapiens
About LUC7L2
This gene has 10 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 34.6), bone marrow (RPKM 32.4) and 25 other tissues.
Summary
This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with Sodium Channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
LUC7L2 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001244585.2 | NP_001231514.1 | putative RNA-binding protein Luc7-like 2 isoform 3 |
| NM_001270643.2 | NP_001257572.1 | putative RNA-binding protein Luc7-like 2 isoform 4 |
| NM_016019.5 | NP_057103.2 | putative RNA-binding protein Luc7-like 2 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
19574390 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16169070 | GOA |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
putative RNA-binding protein Luc7-like 2 |
|
LUC7L2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
LUC7L2 | Q9Y383 | NFYA | Homo sapiens | P23511-2 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | NFYA | Homo sapiens | P23511-2 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | MAP1LC3B | Homo sapiens | Q9GZQ8 | 21900206 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRRM4 | Homo sapiens | A7MD48 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRRM4 | Homo sapiens | A7MD48 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | NFYA | Homo sapiens | P23511 | 25416956 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRSF7 | Homo sapiens | Q16629 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRSF7 | Homo sapiens | Q16629 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRPK1 | Homo sapiens | Q96SB4 | 33961781 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRPK2 | Homo sapiens | P78362 | 33961781 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRPK2 | Homo sapiens | P78362 | 23602568 | |
|
Intra
|
LUC7L2 | Q9Y383 | APPBP2 | Homo sapiens | Q92624 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | APPBP2 | Homo sapiens | Q92624 | 25416956 | |
|
Intra
|
LUC7L2 | Q9Y383 | APPBP2 | Homo sapiens | Q92624 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRSF6 | Homo sapiens | Q13247 | 25416956 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRSF6 | Homo sapiens | Q13247 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | SRSF6 | Homo sapiens | Q13247 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | DZIP1 | Homo sapiens | Q86YF9 | 32296183 | |
|
Intra
|
LUC7L2 | Q9Y383 | DZIP1 | Homo sapiens | Q86YF9 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Childhood Meningioma |
|
|
| Myelodysplastic/Myeloproliferative Neoplasm |
|
|
| Juvenile Pilocytic Astrocytoma |
|
|
| Adult Astrocytic Tumour |
|
|
| Bone Marrow Cancer |
|
|
| Labyrinthitis |
|
|
| Fibrillary Astrocytoma |
|
|
| Spondylometaphyseal Dysplasia, Sedaghatian Type |
|
|
| Pelger-Huet Anomaly |
|
|
| Spinal Cord Ependymoma |
|
|
| Burn-Mckeown Syndrome |
|
|
| Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative |
|
|
| Immunodeficiency 21 |
|
|
| Chronic Neutrophilic Leukemia |
|
|
| Supratentorial Primitive Neuroectodermal Tumor |
|
|
| Placental Choriocarcinoma |
|
|
| Shwachman-Diamond Syndrome 1 |
|
|
| Atypical Teratoid Rhabdoid Tumor |
|
|
| Chronic Leukemia |
|
|
| Neutrophilia, Hereditary |
|
|
| Mandibulofacial Dysostosis, Guion-Almeida Type |
|
|
| Gliomatosis Cerebri |
|
|
| Childhood Astrocytic Tumor |
|
|
| Patau Syndrome |
|
|
| Retinitis Pigmentosa 11 |
|
|
| Spinal Cord Glioma |
|
|
| Peritoneal Mesothelioma |
|
|
| Amegakaryocytic Thrombocytopenia, Congenital |
|
|
| Myxopapillary Ependymoma |
|
|
| Chronic Myelomonocytic Leukemia |
|
|
| Pilomyxoid Astrocytoma |
|
|
| Hereditary Lymphedema |
|
|
| Juvenile Myelomonocytic Leukemia |
|
|
| Erythrocytosis, Familial, 2 |
|
|
| Severe Congenital Neutropenia |
|
|
| Rasopathy |
|
|
| Blood Platelet Disease |
|
|
| Peritoneum Cancer |
|
|
| Myeloproliferative Neoplasm |
|
|
| Blood Coagulation Disease |
|
|
| Li-Fraumeni Syndrome |
|
|
| Diamond-Blackfan Anemia |
|
|
| Myelodysplastic Syndrome |
|
|
| Dyskeratosis Congenita |
|
|
| Refsum Disease, Classic |
|
|
| Leukemia, Acute Myeloid |
|
|
| Hematologic Cancer |
|
|
| Essential Thrombocythemia |
|
|
| Aplastic Anemia |
|
|
| Physical Disorder |
|
|
| Noonan Syndrome 1 |
|
|
| Deficiency Anemia |
|
|
| Fanconi Anemia, Complementation Group A |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Retinitis Pigmentosa |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | LUC7L2 | RGD | RGD:1308651 |
| Mus musculus | LUC7L2 | MGD | MGI:2183260 |