SRSF10 - serine and arginine rich splicing factor 10 Gene

Also Known as NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10772

About SRSF10

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,964,347-23,980,327 (from NCBI)

This gene has 16 transcripts (splice variants), 236 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 28.7), lymph node (RPKM 12.7) and 25 other tissues.

Summary

This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with Other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

SRSF10 Products (8)

mRNA Protein Name
NM_001191005.3 NP_001177934.1 serine/arginine-rich splicing factor 10 isoform 3
NM_001191006.3 NP_001177935.1 serine/arginine-rich splicing factor 10 isoform 4
NM_001191007.3 NP_001177936.1 serine/arginine-rich splicing factor 10 isoform 5
NM_001191009.3 NP_001177938.1 serine/arginine-rich splicing factor 10 isoform 6
NM_001300936.2 NP_001287865.1 serine/arginine-rich splicing factor 10 isoform 8
NM_001300937.2 NP_001287866.1 serine/arginine-rich splicing factor 10 isoform 9
NM_006625.6 NP_006616.1 serine/arginine-rich splicing factor 10 isoform 1
NM_054016.4 NP_473357.1 serine/arginine-rich splicing factor 10 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
26876937 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9774382 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA splicing, via transesterification reactions IDA
IDA: Inferred from direct assay
9774382 GOA
involved in mRNA splice site recognition IDA
IDA: Inferred from direct assay
9774382 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
9774382 GOA
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
11684676 GOA
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
26876937 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
26876937 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
11684676 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF10 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (12 - 81)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 10

  • 40 kDa SR-repressor protein

SRSF10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRSF10 O75494 CLK1 Homo sapiens P49759-3
Validated Y2H
32296183
Intra
SRSF10 O75494 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
SRSF10 O75494 YWHAG Homo sapiens P61981
CoIP
15324660
Intra
SRSF10 O75494 YWHAG Homo sapiens P61981
SLC
36931259
Intra
SRSF10 O75494 RNPS1 Homo sapiens Q15287
Validated Y2H
32296183
Intra
SRSF10 O75494 SFN Homo sapiens P31947
TAP
15778465
Intra
SRSF10 O75494 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
Intra
SRSF10 O75494 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Intra
SRSF10 O75494 CLK3 Homo sapiens P49761
Y2H Array
32296183
Intra
SRSF10 O75494 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alexithymia
Alcoholic Ketoacidosis
Capillary Malformations, Congenital

  • Familial Multiple Nevi Flammei

  • Nevi Flammei, Familial Multiple

  • CMC

  • Port-Wine Stain

  • Capillary Malformations

  • Cmal

  • Familial Multiple Port-Wine Stains

  • Capillary Malformation

  • Capillary Malformations, Congenital, 1, Somatic, Mosaic

  • Congenital Capillary Malformations

  • Port-Wine Stain Familial Multiple

  • Hereditary Capillary Malformations

  • Capillary Malformations, Hereditary

  • Capillary Malformations, Congenital, Type 1, Somatic, Mosaic

  • Strawberry Nevus Of Skin

  • Naevus Flammeus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183831 GPS167 / Unkown
HY-RS13791 SRSF10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19818 Srsf10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25982 Tra2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26314 Srsf10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SRSF10 MGD MGI:1333805
Bos taurus SRSF10 VGNC VGNC:35298
Rattus norvegicus SRSF10 RGD RGD:1311067
Macaca mulatta SRSF10 VGNC VGNC:106502
Felis catus SRSF10 VGNC VGNC:107641
Others SRSF10 NCBI