2. Gene
  3. SREK1 - splicing regulatory glutamic acid and lysine rich protein 1 Gene

SREK1 - splicing regulatory glutamic acid and lysine rich protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SFRS12; SRrp86; SRrp508

Gene ID: 140890 | Gene type: protein coding

About SREK1

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:66,144,300-66,183,615 (from NCBI)

This gene has 16 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 19.8), thyroid (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

SREK1 Products(8)

mRNA Protein Name
NM_001077199.3 NP_001070667.1 splicing regulatory glutamine/lysine-rich protein 1 isoform a
NM_001270492.2 NP_001257421.1 splicing regulatory glutamine/lysine-rich protein 1 isoform c
NM_001323527.2 NP_001310456.1 splicing regulatory glutamine/lysine-rich protein 1 isoform b
NM_001323529.2 NP_001310458.1 splicing regulatory glutamine/lysine-rich protein 1 isoform e
NM_001323533.2 NP_001310462.1 splicing regulatory glutamine/lysine-rich protein 1 isoform f
NM_001323534.2 NP_001310463.1 splicing regulatory glutamine/lysine-rich protein 1 isoform g
NM_001323535.2 NP_001310464.1 splicing regulatory glutamine/lysine-rich protein 1 isoform h
NM_139168.4 NP_631907.1 splicing regulatory glutamine/lysine-rich protein 1 isoform b

SREK1 Protein Structure

(68 - 136)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

splicing regulatory glutamine/lysine-rich protein 1

serine-arginine-rich splicing regulatory protein 508

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13759 SREK1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SREK1 VGNC VGNC:58417
Canis familiaris SREK1 VGNC VGNC:46797
Macaca mulatta SREK1 VGNC VGNC:77944
Mus musculus SREK1 MGD MGI:2145245
Rattus norvegicus SREK1 RGD RGD:621696