TRA2A - transformer 2 alpha homolog Gene

Also Known as AWMS1; HSU53209

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29896

About TRA2A

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,504,780-23,531,981 (from NCBI)

This gene has 12 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 46.2), endometrium (RPKM 25.7) and 25 other tissues.

Summary

This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

TRA2A Products (7)

mRNA	Protein	Name
NM_001282757.2	NP_001269686.1	transformer-2 protein homolog alpha isoform 2
NM_001282758.2	NP_001269687.1	transformer-2 protein homolog alpha isoform 2
NM_001282759.2	NP_001269688.1	transformer-2 protein homolog alpha isoform 3
NM_001362759.2	NP_001349688.1	transformer-2 protein homolog alpha isoform 4
NM_001362760.2	NP_001349689.1	transformer-2 protein homolog alpha isoform 2
NM_001362761.2	NP_001349690.1	transformer-2 protein homolog alpha isoform 2
NM_013293.5	NP_037425.1	transformer-2 protein homolog alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23602568	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	9546399	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9546399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRA2A Protein Structure

RRM_1

0
100
200
282 a.a.

Protein Preferred Names	Protein Names
transformer-2 protein homolog alpha	TRA-2 alpha

TRA2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRA2A	Q13595	RNPS1	Homo sapiens	Q15287	Validated Y2H	32296183
Intra	TRA2A	Q13595	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	TRA2A	Q13595	MAGOHB	Homo sapiens	Q96A72	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TRA2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87264	TRA2A Antibody	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Malignant Pineal Area Germ Cell Neoplasm	Pineal Germ Cell Tumor Malignant Pineal Parenchymal Germ Cell Tumor Pineal Region Germ Cell Tumor Pineal Cell Tumor Pineal Cell Tumour Pineal Region Germinoma Malignant Pineal Region Germ Cell Tumor Pineal Germinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14961	TRA2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRA2A	VGNC	VGNC:36267
Mus musculus	TRA2A	MGD	MGI:1933972
Canis familiaris	TRA2A	VGNC	VGNC:47758
Macaca mulatta	TRA2A	VGNC	VGNC:79040
Rattus norvegicus	TRA2A	RGD	RGD:1562563
Felis catus	TRA2A	VGNC	VGNC:66490