SRSF5 - serine and arginine rich splicing factor 5 Gene

Also Known as HRS; SFRS5; SRP40

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6430

About SRSF5

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,767,142-69,772,005 (from NCBI)

This gene has 19 transcripts (splice variants), 204 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 175.0), skin (RPKM 153.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SRSF5 Products (4)

mRNA	Protein	Name
NM_001039465.2	NP_001034554.1	serine/arginine-rich splicing factor 5 isoform 1
NM_001320214.2	NP_001307143.1	serine/arginine-rich splicing factor 5 isoform 1
NM_001411040.1	NP_001397969.1	serine/arginine-rich splicing factor 5 isoform 2
NM_006925.5	NP_008856.2	serine/arginine-rich splicing factor 5 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12762840	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF5 Protein Structure

RRM_1

0
100
200
272 a.a.

Protein Preferred Names	Protein Names
serine/arginine-rich splicing factor 5	SR splicing factor 5

SRSF5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRSF5	Q13243	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	SRSF5	Q13243	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
Intra	SRSF5	Q13243	ZRSR2	Homo sapiens	Q15696	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SRSF5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811141	SRSF5 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Retinal Melanoma	Malignant Retinal Melanoma Malignant Melanoma Of Retina
Aleutian Mink Disease	Aleutian Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13796	SRSF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22832	Srsf5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SRSF5	VGNC	VGNC:52831
Felis catus	SRSF5	VGNC	VGNC:65697
Macaca mulatta	SRSF5	VGNC	VGNC:99245
Mus musculus	SRSF5	MGD	MGI:98287
Canis familiaris	SRSF5	VGNC	VGNC:51690
Rattus norvegicus	SRSF5	RGD	RGD:3664
Others	SRSF5	NCBI