CLK1/2-IN-3
LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs.
For research use only. We do not sell to patients.
- CAS No.: 1005784-60-0
- Formula: C21H21N5O2
- Molecular Weight:375.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
CLK1 1.1 nM (IC50) |
CLK2 2.1 nM (IC50) |
SRPK1 130 nM (IC50) |
SRPK2 260 nM (IC50) |
SRPK3 260 nM (IC50) |
CLK1/2-IN-3 (compound 3) (1.1-3.3 μM; 72 h) increases the expression of S6K mRNAs in MDA-MB-468 cells[1].
CLK1/2-IN-3 (5 μM) significantly reduces the levels of endogenous phosphorylated SR proteins[1].
CLK1/2-IN-3 (1-10 μM) shows anti-proliferative activity with GI50s of 3.4, 2.6, 2.1, 2.5, 2.2, 2.9, 1.5 μM for MDA-MB-468, A549, COLO205, HCT-116, NCI-H23, SW620, COLO320DM cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1005784-60-0
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Molecular Weight 375.42
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Formula C21H21N5O2
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SMILES
O=C(NC1=CN2C=C(C3=CNN=C3)C=CC2=N1)C4=CC=C(C(C)(C)CO)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CLK1/2-IN-3 Related Classifications
HY-113831 Related Classifications
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