ZNF263 - zinc finger protein 263 Gene

Also Known as FPM315; ZSCAN44; ZKSCAN12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10127

About ZNF263

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,283,491-3,301,401 (from NCBI)

This gene has 7 transcripts (splice variants), 137 orthologues and 31 paralogues. Ubiquitous expression in ovary (RPKM 7.9), testis (RPKM 7.1) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF263 Products (2)

mRNA Protein Name
NM_001411015.1 NP_001397944.1 zinc finger protein 263 isoform 2
NM_005741.5 NP_005732.2 zinc finger protein 263 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19887448 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
32051553 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19887448 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
32277030 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
26089202 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
32051553 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF263 Protein Structure

SCAN

SCAN: SCAN domain (36 - 129)

KRAB

KRAB: KRAB box (219 - 256)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (380 - 400)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (448 - 472)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (476 - 501)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (504 - 529)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (589 - 614)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (617 - 642)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (648 - 669)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

zinc finger protein 263

  • zinc finger protein FPM315

ZNF263 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF263 O14978 ZSCAN22 Homo sapiens P10073
Validated Y2H
32296183
Intra
ZNF263 O14978 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
Intra
ZNF263 O14978 PPL Homo sapiens O60437
Validated Y2H
32296183
Intra
ZNF263 O14978 TRIM41 Homo sapiens Q8WV44
Anti Tag CoIP
33961781
Intra
ZNF263 O14978 TRIM41 Homo sapiens Q8WV44
Anti Tag CoIP
28514442
Intra
ZNF263 O14978 TRIM41 Homo sapiens Q8WV44
Y2H Pooling
16189514
Intra
ZNF263 O14978 TRIM41 Homo sapiens Q8WV44
Validated Y2H
32296183
Intra
ZNF263 O14978 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
ZNF263 O14978 ZNF165 Homo sapiens P49910
Validated Y2H
32296183
Intra
ZNF263 O14978 CLK3 Homo sapiens P49761
Y2H Prey Pooling
25416956
Intra
ZNF263 O14978 CLK3 Homo sapiens P49761
Y2H Array
25416956
Intra
ZNF263 O14978 SCAND1 Homo sapiens P57086
Validated Y2H
32296183
Intra
ZNF263 O14978 SCAND1 Homo sapiens P57086
Y2H Pooling
16189514
Intra
ZNF263 O14978 SCAND1 Homo sapiens P57086
Anti Tag CoIP
33961781
Intra
ZNF263 O14978 SCAND1 Homo sapiens P57086
Anti Tag CoIP
28514442
Intra
ZNF263 O14978 CLK2 Homo sapiens P49760
Y2H Array
25416956
Intra
ZNF263 O14978 CLK2 Homo sapiens P49760
Validated Y2H
25416956
Intra
ZNF263 O14978 TCAF1 Homo sapiens Q9Y4C2
Y2H Prey Pooling
25416956
Intra
ZNF263 O14978 TCAF1 Homo sapiens Q9Y4C2
Validated Y2H
25416956
Intra
ZNF263 O14978 JAKMIP2 Homo sapiens Q96AA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 12

  • Combined Immunodeficiency Due To Malt1 Deficiency

  • IMD12

  • Immunodeficiency, Type 12
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16115 ZNF263 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZNF263 VGNC VGNC:37234
Macaca mulatta ZNF263 VGNC VGNC:78888
Mus musculus ZNF263 MGD MGI:1921370
Felis catus ZNF263 VGNC VGNC:80706
Canis familiaris ZNF263 VGNC VGNC:48683
Rattus norvegicus ZNF263 RGD RGD:1307301
Others ZNF263 NCBI