PPL - periplakin Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5493

About PPL

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,882,507-4,937,148 (from NCBI)

This gene has 6 transcripts (splice variants), 123 orthologues and 2 paralogues. Biased expression in esophagus (RPKM 300.0) and skin (RPKM 63.7).

Summary

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. Akt1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

PPL Products (1)

mRNA	Protein	Name
NM_002705.5	NP_002696.4	periplakin

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12244133	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19211270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPL Protein Structure

Plectin

0
300
600
900
1200
1500
1756 a.a.

Protein Preferred Names	Protein Names
periplakin	190 kDa paraneoplastic pemphigus antigen

PPL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPL	O60437	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	PPL	O60437	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	PPL	O60437	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	PPL	O60437	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	PPL	O60437	DES	Homo sapiens	P17661	Validated Y2H	32296183
Intra	PPL	O60437	DES	Homo sapiens	P17661	Y2H Array	32296183
Intra	PPL	O60437	DES	Homo sapiens	P17661	Y2H Prey Pooling	32296183
Intra	PPL	O60437	C6orf141	Homo sapiens	Q5SZD1	Y2H Array	32296183
Intra	PPL	O60437	C6orf141	Homo sapiens	Q5SZD1	Y2H Prey Pooling	32296183
Intra	PPL	O60437	C6orf141	Homo sapiens	Q5SZD1	Validated Y2H	32296183
Intra	PPL	O60437	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	PPL	O60437	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	PPL	O60437	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	PPL	O60437	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	PPL	O60437	KRT39	Homo sapiens	Q6A163	Validated Y2H	32296183
Intra	PPL	O60437	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	PPL	O60437	KCTD21	Homo sapiens	Q4G0X4	Validated Y2H	32296183
Intra	PPL	O60437	KCTD21	Homo sapiens	Q4G0X4	Y2H Prey Pooling	32296183
Intra	PPL	O60437	KCTD21	Homo sapiens	Q4G0X4	Y2H Array	32296183
Intra	PPL	O60437	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	PPL	O60437	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	PPL	O60437	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0-7	Validated Y2H	32296183
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0-7	Y2H Prey Pooling	32296183
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0-7	Y2H Array	32296183
Intra	PPL	O60437	POF1B	Homo sapiens	Q8WVV4-1	Y2H Prey Pooling	32296183
Intra	PPL	O60437	POF1B	Homo sapiens	Q8WVV4-1	Validated Y2H	32296183
Intra	PPL	O60437	POF1B	Homo sapiens	Q8WVV4-1	Y2H Array	32296183
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4-2	Validated Y2H	32296183
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4-2	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4-2	Y2H Array	32296183
Intra	PPL	O60437	PLEKHA7	Homo sapiens	Q6IQ23-2	Y2H Prey Pooling	32296183
Intra	PPL	O60437	PLEKHA7	Homo sapiens	Q6IQ23-2	Validated Y2H	32296183
Intra	PPL	O60437	PLEKHA7	Homo sapiens	Q6IQ23-2	Y2H Array	32296183
Intra	PPL	O60437	ZNF213	Homo sapiens	O14771	Y2H Array	32296183
Intra	PPL	O60437	ZNF213	Homo sapiens	O14771	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZNF474	Homo sapiens	Q6S9Z5	Y2H Array	32296183
Intra	PPL	O60437	ZNF474	Homo sapiens	Q6S9Z5	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZNF474	Homo sapiens	Q6S9Z5	Validated Y2H	32296183
Intra	PPL	O60437	AHCYL1	Homo sapiens	O43865	Y2H Prey Pooling	25416956
Intra	PPL	O60437	HECTD3	Homo sapiens	Q5T447	Y2H Prey Pooling	32296183
Intra	PPL	O60437	HECTD3	Homo sapiens	Q5T447	Y2H Array	32296183
Intra	PPL	O60437	HECTD3	Homo sapiens	Q5T447	Validated Y2H	32296183
Intra	PPL	O60437	AKT1	Homo sapiens	P31749	Y2H	18624398
Intra	PPL	O60437	VIM	Homo sapiens	P08670	Validated Y2H	25416956
Intra	PPL	O60437	VIM	Homo sapiens	P08670	Y2H Array	25416956
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	PPL	O60437	KNSTRN	Homo sapiens	Q9Y448	Y2H Array	32296183
Intra	PPL	O60437	KNSTRN	Homo sapiens	Q9Y448	Validated Y2H	32296183
Intra	PPL	O60437	KNSTRN	Homo sapiens	Q9Y448	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Y2H Array	32296183
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	25416956
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Validated Y2H	25416956
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Validated Y2H	32296183
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Y2H Array	25416956
Intra	PPL	O60437	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	PPL	O60437	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	PPL	O60437	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PPL	O60437	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PPL	O60437	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PPL	O60437	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4	Validated Y2H	25416956
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4	Y2H Prey Pooling	25416956
Intra	PPL	O60437	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	PPL	O60437	ANXA9	Homo sapiens	O76027	IF	22841549
Intra	PPL	O60437	ANXA9	Homo sapiens	O76027	Anti Tag CoIP	22841549
Intra	PPL	O60437	MRPL28	Homo sapiens	Q13084	Y2H Prey Pooling	32296183
Intra	PPL	O60437	MRPL28	Homo sapiens	Q13084	Validated Y2H	32296183
Intra	PPL	O60437	MRPL28	Homo sapiens	Q13084	Y2H Array	32296183
Intra	PPL	O60437	ZSCAN16	Homo sapiens	Q9H4T2	Validated Y2H	32296183
Intra	PPL	O60437	ZSCAN16	Homo sapiens	Q9H4T2	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZSCAN16	Homo sapiens	Q9H4T2	Y2H Array	32296183
Intra	PPL	O60437	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Prey Pooling	25416956
Intra	PPL	O60437	ZNF165	Homo sapiens	P49910	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZNF165	Homo sapiens	P49910	Validated Y2H	32296183
Intra	PPL	O60437	ZNF165	Homo sapiens	P49910	Y2H Array	32296183
Intra	PPL	O60437	UPRT	Homo sapiens	Q96BW1	Y2H Prey Pooling	32296183
Intra	PPL	O60437	UPRT	Homo sapiens	Q96BW1	Y2H Array	32296183
Intra	PPL	O60437	UPRT	Homo sapiens	Q96BW1	Validated Y2H	32296183
Intra	PPL	O60437	ZNF263	Homo sapiens	O14978	Y2H Array	32296183
Intra	PPL	O60437	ZNF263	Homo sapiens	O14978	Y2H Prey Pooling	32296183
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0	Validated Y2H	25416956
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0	Y2H Array	25416956
Intra	PPL	O60437	RALBP1	Homo sapiens	Q15311	Y2H Prey Pooling	25416956
Intra	PPL	O60437	ACTR5	Homo sapiens	Q9H9F9	Validated Y2H	32296183
Intra	PPL	O60437	ACTR5	Homo sapiens	Q9H9F9	Y2H Array	32296183
Intra	PPL	O60437	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	PPL	O60437	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	PPL	O60437	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Paraneoplastic Pemphigus
Pemphigus
Pemphigus Foliaceus	Pemphigus Foliaceous Pf Superficial Pemphigus
Pemphigus Vulgaris, Familial	Pemphigus Vulgaris Familial Pemphigus Vulgaris Pemphigus
Bullous Pemphigoid	Benign Pemphigus Senile Dermatitis Herpetiformis Old Age Pemphigus Parapemphigus Pemphigoid Pemphigoid Bullous Pemphigoid, Bullous
Pemphigoid
Bronchiolitis Obliterans	Bronchiolitis Fibrosa Obliterans Obliterative Bronchiolitis Bronchiolitis Exudativa Bronchiolitis, Exudative
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Pseudomembranous Conjunctivitis
Iga Pemphigus
Subcorneal Pustular Dermatosis	Subcorneal Pustular Dermatitis Sneddon-Wilkinson Disease Or Syndrome Pustulosis Subcornealis Sneddon-Wilkinson Disease Skin Diseases, Vesiculobullous Vesiculobullous Skin Disease
Bullous Skin Disease	Skin Diseases Bullous Skin Diseases, Bullous
Pemphigoid Gestationis	Herpes Gestationis Gestational Pemphigoid Gestational Herpes
Microcephaly And Chorioretinopathy 2
Acute Conjunctivitis
Lichen Disease
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107098	PPL-100 free acid		/	Unkown
HY-159917	PPL agonist-1		/	Unkown
HY-RS10959	PPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18900	Ppl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25391	Ppl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPL	MGD	MGI:1194898
Canis familiaris	PPL	VGNC	VGNC:44861
Rattus norvegicus	PPL	RGD	RGD:1305511
Felis catus	PPL	VGNC	VGNC:68991
Bos taurus	PPL	VGNC	VGNC:33208
Macaca mulatta	PPL	VGNC	VGNC:76240
Others	PPL	NCBI