OAS2 - 2'-5'-oligoadenylate synthetase 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4939

About OAS2

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,978,519-113,011,723 (from NCBI)

This gene has 15 transcripts (splice variants), 110 orthologues and 3 paralogues. Broad expression in spleen (RPKM 18.2), lymph node (RPKM 14.1) and 22 other tissues.

Summary

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral Infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

OAS2 Products (3)

mRNA	Protein	Name
NM_001032731.2	NP_001027903.1	2'-5'-oligoadenylate synthase 2 isoform 3
NM_002535.3	NP_002526.2	2'-5'-oligoadenylate synthase 2 isoform 2
NM_016817.3	NP_058197.2	2'-5'-oligoadenylate synthase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 2'-5'-oligoadenylate synthetase activity	IDA IDA: Inferred from direct assay	9880569	GOA
enables 2'-5'-oligoadenylate synthetase activity	IMP IMP: Inferred from mutant phenotype	10464285	GOA
enables ATP binding	IMP IMP: Inferred from mutant phenotype	10464285	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	9880569	GOA
enables double-stranded RNA binding	IMP IMP: Inferred from mutant phenotype	10464285	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in interleukin-27-mediated signaling pathway	IDA IDA: Inferred from direct assay	32270034	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	30822544	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19923450	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19923450	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OAS2 Protein Structure

OAS1_C

NTP_transf_2

OAS1_C

0
200
400
600
719 a.a.

Protein Preferred Names	Protein Names
2'-5'-oligoadenylate synthase 2	(2'-5')oligo(A) synthetase 2

OAS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OAS2	P29728	CLK3	Homo sapiens	P49761	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Tick-Borne Encephalitis	Siberian Tick-Borne Encephalitis Encephalitis, Tick-Borne Central European Encephalitis Far Eastern Tbe Russian Spring-Summer Encephalitis Taiga Encephalitis West-Siberian Encephalitis Western European Tick-Borne Encephalitis Tbe Encephalitis Tick-Borne Encephalitis, Central European Encephalitis, Far Eastern Russian

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09728	OAS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20316	Oas2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26824	Oas2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OAS2	RGD	RGD:1359697
Felis catus	OAS2	VGNC	VGNC:68607
Canis familiaris	OAS2	VGNC	VGNC:44087
Mus musculus	OAS2	MGD	MGI:2180852
Macaca mulatta	OAS2	VGNC	VGNC:75571
Bos taurus	OAS2	VGNC	VGNC:32391
Others	OAS2	NCBI