1. Cell Cycle/DNA Damage
  2. CDK
  3. KH-CB19

KH-CB19 

Cat. No.: HY-12828 Purity: 99.31%
Handling Instructions

KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).

For research use only. We do not sell to patients.

KH-CB19 Chemical Structure

KH-CB19 Chemical Structure

CAS No. : 1354037-26-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 312 In-stock
Estimated Time of Arrival: December 31
1 mg USD 96 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Description

KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4). IC50 value: 20 nM (CLK1) [1] Target: CLK1/4 inhibitor in vitro: KH-CB19 showed potent inhibition of CLK1 with an IC50 of 20 nM, and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls.Treatment of resting cells with 10 μM KH-CB19 significantly reduced the basal expression of flTF as well as asHTF [1].

IC50 & Target[1]

CLK1

19.7 nM (IC50)

CLK3

530 nM (IC50)

DYRK1A

55.2 nM (IC50)

Molecular Weight

338.19

Formula

C₁₅H₁₃Cl₂N₃O₂

CAS No.

1354037-26-5

SMILES

O=C(C(N1C)=C(/C(C#N)=C\N)C2=C1C(Cl)=C(Cl)C=C2)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (147.85 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9569 mL 14.7846 mL 29.5692 mL
5 mM 0.5914 mL 2.9569 mL 5.9138 mL
10 mM 0.2957 mL 1.4785 mL 2.9569 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

KH-CB19CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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Product name:
KH-CB19
Cat. No.:
HY-12828
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