1. Cell Cycle/DNA Damage
  2. CDK
  3. KH-CB19


Cat. No.: HY-12828 Purity: 98.03%
COA Handling Instructions

KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM).

For research use only. We do not sell to patients.

KH-CB19 Chemical Structure

KH-CB19 Chemical Structure

CAS No. : 1354037-26-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 462 In-stock
1 mg USD 96 In-stock
5 mg USD 420 In-stock
10 mg USD 630 In-stock
25 mg USD 1130 In-stock
50 mg USD 1700 In-stock
100 mg USD 2500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Other Forms of KH-CB19:

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KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM)[1][2].

IC50 & Target[1]


19.7 nM (IC50)


530 nM (IC50)


55.2 nM (IC50)

In Vitro

KH-CB19 (10 μM; 1 h) shows CLK inhibition on SR protein phosphorylation in human microvascular endothelial cells[1].
KH-CB19 (50 μM; 6 h) inhibits the disruption by CLK4 in A549 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human microvascular endothelial cells (HMEC-1)
Concentration: 10 μM
Incubation Time: 1 hour
Result: Led to a reduced phosphorylation of SRp75, SRp55, and SRp20 compared with non TNF-α-stimulated controls.
Led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls.
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (147.85 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9569 mL 14.7846 mL 29.5692 mL
5 mM 0.5914 mL 2.9569 mL 5.9138 mL
10 mM 0.2957 mL 1.4785 mL 2.9569 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.31%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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