2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. CDK Wnt
  4. Ipivivint

Ipivivint (compound 38) is a potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM).

For research use only. We do not sell to patients.

Ipivivint Chemical Structure

Ipivivint Chemical Structure

CAS No. : 1481617-15-5

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Based on 1 publication(s) in Google Scholar

Ipivivint Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

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Description

Ipivivint (compound 38) is a potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM)[1].

IC50 & Target[1]

CDK2

1 nM (EC50)

CDK3

7 nM (EC50)

In Vitro

Ipivivint Related Antibodies

Western Blot Analysis[1]

Cell Line: SW480 cells
Concentration: 0.01~10 μM
Incubation Time: 1 hour
Result: Potently inhibited SRSF5/6 phosphorylation.

Apoptosis Analysis[1]

Cell Line: SW480 cells
Concentration: 0.01~10 μM
Incubation Time: 0.03 μM~3 μM
Result: Induced apoptosis.

RT-PCR[1]

Cell Line: HEK-293T cells
Concentration: 0.3~3 μM
Incubation Time: 1 hour
Result: Inhibited Wnt/β-catenin signaling induced by Wnt3a.

Immunofluorescence[1]

Cell Line: SW480 cells
Concentration: 0.3~10 μM
Incubation Time: 6 hours
Result: Increased nuclear speckle enlargement.
In Vivo
Animal Model: Foxn1 mice[1]
Dosage: 25 mg/kg
Administration: P.o.
Result: Potently inhibited tumor SRSF6 phosphorylation.
Clinical Trial
Molecular Weight

464.50

Formula

C26H21FN8
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN(C)CC1=CC(C2=CN=C(NN=C3C(N4)=NC5=C4C(C6=CC(F)=CC=C6)=CN=C5)C3=C2)=CN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (7.17 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1529 mL 10.7643 mL 21.5285 mL
5 mM 0.4306 mL 2.1529 mL 4.3057 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1529 mL 10.7643 mL 21.5285 mL 53.8213 mL
5 mM 0.4306 mL 2.1529 mL 4.3057 mL 10.7643 mL
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Ipivivint Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ipivivint1481617-15-5CDKWntCyclin dependent kinaseCLK2CLK3Inhibitorinhibitorinhibit

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