1. Cell Cycle/DNA Damage
  2. CDK
  3. K00546

K00546 

Cat. No.: HY-103647 Purity: 98.78%
Handling Instructions

K00546 is a potent CDK1 and CDK2 inhibitor and is a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively. K00546 is also a triazole-1-carbothioamide inhibitor.

For research use only. We do not sell to patients.

K00546 Chemical Structure

K00546 Chemical Structure

CAS No. : 443798-47-8

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 308 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

K00546 is a potent CDK1 and CDK2 inhibitor and is a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively. K00546 is also a triazole-1-carbothioamide inhibitor[1][2].

IC50 & Target[1][2]

CLK1

8.9 nM (IC50)

CLK3

29.2 nM (IC50)

CDK1

 

CDK2

 

In Vitro

K00546 binds to the SLK ATP-binding site forming three hydrogen bonds with the kinase hinge residues E109 and C111. The sulphamoyl moiety of K00546 also interacts with the main chain of L40[1].

Molecular Weight

425.44

Formula

C₁₅H₁₃F₂N₇O₂S₂

CAS No.

443798-47-8

SMILES

S=C(N1N=C(NC2=CC=C(S(=O)(N)=O)C=C2)N=C1N)NC3=C(F)C=CC=C3F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (235.05 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3505 mL 11.7525 mL 23.5051 mL
5 mM 0.4701 mL 2.3505 mL 4.7010 mL
10 mM 0.2351 mL 1.1753 mL 2.3505 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

K00546K 00546K-00546CDKCyclin dependent kinaseCLK1CLK3pyrazole-quinazolineCDK1CDK2triazole-1-carbothioamideSLKInhibitorinhibitorinhibit

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K00546
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HY-103647
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