UBL5 Antibody (YA10075)
(Synonyms: Transcriptional activator protein Pur-beta; Purine-rich element-binding protein B)UBL5 Antibody (YA10075) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to UBL5.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
UBL5 Antibody (YA10075) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to UBL5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 8 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 8 kDa
Purified recombinant protein of human UBL5.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
UBL5 is an Ubiquitin-like protein that plays a role in cell proliferation and sister chromatid cohesion by associating with spliceosomal proteins. Participates thereby in pre-mRNA splicing by maintaining spliceosome integrity. Promotes the functional integrity of the Fanconi anemia DNA repair pathway by interacting with FANCI component and subsequently mediating the formation of FANCI homodimers. Also plays a protective role against ER stress-induced apoptosis[1][2][3].
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Subcellular Localization
Cytoplasm; Nucleus; Nucleus, Cajal body
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Expression
Tissue_Specificity: Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts.
Induction: Depleted by ER stress-induced mediated by the ubiquitin-independent proteasome system independent of transcriptional regulation and downstream of PERK activation. -
Isoforms & Post-Translational Modification
UBL5 has an amino acid length of 73, molecular weight is 8547 Da.
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Subunit
Interacts with CLK1, CLK3 and CLK4.
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SwissProt ID
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Synonyms
Transcriptional activator protein Pur-beta; Purine-rich element-binding protein B
Documentation
References
[1]. Oka Y, et al. UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells. EMBO Rep. 2014 Sep;15(9):956-64. [Content Brief]
[2]. Oka Y, et al. Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway. EMBO J. 2015 May 12;34(10):1385-98. [Content Brief]
[3]. Wang W, et al. Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death. J Biol Chem. 2023 Jul;299(7):104915. [Content Brief]
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