2. Gene
  3. DTNA - dystrobrevin alpha Gene

DTNA - dystrobrevin alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DTN; DRP3; DTN-A; LVNC1; D18S892E

Gene ID: 1837 | Gene type: protein coding

About DTNA

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:34,493,312-34,891,844 (from NCBI)

This gene has 65 transcripts (splice variants), 225 orthologues, 36 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 27.5), heart (RPKM 10.7) and 10 other tissues.

Summary

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

DTNA Products(44)

mRNA Protein Name
NM_001128175.2 NP_001121647.1 dystrobrevin alpha isoform 9
NM_001198938.2 NP_001185867.1 dystrobrevin alpha isoform 10
NM_001198939.2 NP_001185868.1 dystrobrevin alpha isoform 11
NM_001198940.2 NP_001185869.1 dystrobrevin alpha isoform 12
NM_001198941.2 NP_001185870.1 dystrobrevin alpha isoform 13
NM_001198942.1 NP_001185871.1 dystrobrevin alpha isoform 14
NM_001198943.1 NP_001185872.1 dystrobrevin alpha isoform 15
NM_001198944.1 NP_001185873.1 dystrobrevin alpha isoform 16
NM_001198945.2 NP_001185874.1 dystrobrevin alpha isoform 17
NM_001386753.1 NP_001373682.1 dystrobrevin alpha isoform 10
NM_001386754.1 NP_001373683.1 dystrobrevin alpha isoform 18
NM_001386755.1 NP_001373684.1 dystrobrevin alpha isoform 18
NM_001386756.1 NP_001373685.1 dystrobrevin alpha isoform 18
NM_001386757.1 NP_001373686.1 dystrobrevin alpha isoform 18
NM_001386758.1 NP_001373687.1 dystrobrevin alpha isoform 18
NM_001386759.1 NP_001373688.1 dystrobrevin alpha isoform 18
NM_001386760.1 NP_001373689.1 dystrobrevin alpha isoform 19
NM_001386761.1 NP_001373690.1 dystrobrevin alpha isoform 2
NM_001386762.1 NP_001373691.1 dystrobrevin alpha isoform 20
NM_001386763.1 NP_001373692.1 dystrobrevin alpha isoform 12
NM_001386764.1 NP_001373693.1 dystrobrevin alpha isoform 12
NM_001386765.1 NP_001373694.1 dystrobrevin alpha isoform 12
NM_001386766.1 NP_001373695.1 dystrobrevin alpha isoform 12
NM_001386767.1 NP_001373696.1 dystrobrevin alpha isoform 12
NM_001386768.1 NP_001373697.1 dystrobrevin alpha isoform 21
NM_001386769.1 NP_001373698.1 dystrobrevin alpha isoform 21
NM_001386770.1 NP_001373699.1 dystrobrevin alpha isoform 22
NM_001386771.1 NP_001373700.1 dystrobrevin alpha isoform 13
NM_001386772.1 NP_001373701.1 dystrobrevin alpha isoform 13
NM_001386773.1 NP_001373702.1 dystrobrevin alpha isoform 23
NM_001386774.1 NP_001373703.1 dystrobrevin alpha isoform 23
NM_001386775.1 NP_001373704.1 dystrobrevin alpha isoform 7
NM_001386776.1 NP_001373705.1 dystrobrevin alpha isoform 9
NM_001386777.1 NP_001373706.1 dystrobrevin alpha isoform 9
NM_001386788.1 NP_001373717.1 dystrobrevin alpha isoform 24
NM_001386795.1 NP_001373724.1 dystrobrevin alpha isoform 24
NM_001390.5 NP_001381.2 dystrobrevin alpha isoform 1
NM_001391.5 NP_001382.2 dystrobrevin alpha isoform 3
NM_001392.5 NP_001383.2 dystrobrevin alpha isoform 7
NM_032975.4 NP_116757.2 dystrobrevin alpha isoform 2
NM_032978.7 NP_116760.2 dystrobrevin alpha isoform 4
NM_032979.5 NP_116761.2 dystrobrevin alpha isoform 5
NM_032980.4 NP_116762.2 dystrobrevin alpha isoform 6
NM_032981.5 NP_116763.1 dystrobrevin alpha isoform 8

DTNA Protein Structure

EF-hand_2

EF-hand_2: EF hand (15 - 140)

EF-hand_3

EF-hand_3: EF-hand (144 - 232)

ZZ

ZZ: Zinc finger, ZZ type (240 - 280)

  • 0
  • 200
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  • 600
  • 743 a.a.
Protein Preferred Names Protein Names

dystrobrevin alpha

dystrophin-related protein 3

Related Diseases

Diseases Alias
Left Ventricular Noncompaction 1

LVNC1

Left Ventricular Noncompaction 1, With Or Without Congenital Heart Defects

Left Ventricular Noncompaction 1 With Or Without Congenital Heart Defects

Left Ventricular Non-Compaction 1

Left Ventricular Non-Compaction With Or Without Congenital Heart Defects

Non-Compaction Of Left Ventricular Myocardium Isolated Autosomal Dominant Type 1

Non-Compaction Of Left Ventricular Myocardium With Congenital Heart Defects

Ventricular Noncompaction, Left, Type 1

Noncompaction Of Left Ventricular Myocardium, Familial Isolated, Autosomal Dominant 1
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy
Meniere Disease

Meniere'S Disease

Otogenic Vertigo

Ménière Disease

Ménière'S Disease

Mnire'S Vertigo

Auditory Vertigo

Aural Vertigo

Meniere'S Syndrome

Ménière'S Vertigo

Primary Endolymphatic Hydrops

Menieres Disease

Vertigo, Aural

Labyrinth Hydrops

Labyrinthine Hydrops

Labyrinthine Vertigo

Ménière Syndrome

Ménière Vertigo

Idiopathic Endolymphatic Hydrops
Barth Syndrome

3-Methylglutaconic Aciduria Type 2

BTHS

Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria

Mga Type Ii

Mga2

Mgca2

Mga Type 2

3-Methylglutaconic Aciduria Type Ii

3-Methylglutaconic Aciduria, Type Ii

Mga, Type Ii

3-Methylglutaconicaciduria Type 2

3-Methylglutaconicaciduria Type Ii

Taz Defect

3 Methylglutaconic Aciduria, Type Ii

Dnajc19 Defect

Cardioskeletal Myopathy-Neutropenia Syndrome

X-Linked Cardioskeletal Myopathy And Neutropenia

3-Alpha-Methylglutaconic Aciduria Type 2

Agm2

Cardioskeletal Myopathy-Neutropenia

Invm

Left Ventricular Non-Compaction Isolated X-Linked

Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked

Agammaglobulinemia 2, Autosomal Recessive
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Peripheral Vertigo

Vertigo, Peripheral
Muscular Dystrophy, Duchenne Type

Duchenne Muscular Dystrophy

DMD

Muscular Dystrophy, Duchenne

Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type

Severe Dystrophinopathy, Duchenne Type

Muscular Dystrophy Duchenne

Dystrophy, Muscular, Duchenne Type

Benign Duchenne Muscular Dystrophy

Duchenne Motor Neuron Disease

Duchenne Type Dystrophy

Duchenne-Griesinger Disease
Ebstein Anomaly

Ebstein'S Anomaly

Ebstein'S Anomaly Of Common Atrioventricular Valve

Ebstein'S Anomaly Of Right Atrioventricular Valve

Ebstein'S Anomaly Of Tricuspid Valve

Ebstein'S Malformation

Ebstein Malformation Of The Tricuspid Valve

Ebstein Anomaly Of The Tricuspid Valve

Ebstein Disease

Accessory Tricuspid Valve Tissue

Congenital Ebstein Deformity Of Tricuspid Valve

Ebstein Syndrome

Ebstein Cardiopathy

Ebstein Anomaly Of Tricuspid Valve
Myopathy

Muscular Diseases

Myopathies
Muscular Dystrophy, Becker Type

Becker Muscular Dystrophy

BMD

Benign Pseudohypertrophic Muscular Dystrophy

Benign Congenital Myopathy

Becker Dystrophinopathy

Becker'S Muscular Dystrophy

Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type

Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type

Muscular Dystrophy Becker

Dystrophy, Muscular, Becker Type

Dystrophinopathy

Becker Dystrophy

Becker Type Dystrophy

Bmd - [Becker Muscular Dystrophy]
Vestibular Disease

Vestibular Diseases

Vertigo, Vestibular Disorder

Vestibular Disorder

Diseases Of Inner Ear
Muscular Dystrophy, Congenital, Lmna-Related

Congenital Muscular Dystrophy

Congenital Muscular Dystrophy Due To Lmna Mutation

MDCL

L-Cmd

Lmna-Related Congenital Muscular Dystrophy

Muscular Dystrophy, Congenital

Congenital Muscular Dystrophy Lmna-Related

Lmna-Related Cmd

Cmd

Mdc

Muscular Dystrophy Congenital Lmna-Related

Dystrophy, Muscular, Congenital, Lmna-Related

Dystrophy, Muscular, Congenital

Hereditary Muscular Dystrophy

Congenital Hereditary Muscular Dystrophy

Congenital Progressive Muscular Dystrophy

Hereditary Progressive Muscular Dystrophy
Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Congenital Myasthenic Syndrome

Congenital Myasthenia

Congenital Myasthenic Syndromes

Cms

Myasthenic Syndromes, Congenital

Myasthenic Syndromes Congenital

Myasthenic Syndrome, Congenital

Congenital Myasthenic Syndrome Ib

Congenital And Developmental Myasthenia

Developmental Myasthenia
Neuromuscular Disease

Neuromuscular Diseases

Neuromuscular Disorders

Neuromuscular Disorder
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04035 DTNA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DTNA VGNC VGNC:61643
Mus musculus DTNA MGD MGI:106039
Macaca mulatta DTNA VGNC VGNC:72007
Rattus norvegicus DTNA RGD RGD:1561985
Canis familiaris DTNA VGNC VGNC:40114
Bos taurus DTNA VGNC VGNC:28231