MXD3 - MAX dimerization protein 3 Gene

Homo sapiens

Also known as MYX; MAD3; BHLHC13

Gene ID: 83463 | Gene type: protein coding

About MXD3

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,305,499-177,312,752 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 15.2), colon (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

MXD3 Products(4)

mRNA	Protein	Name
NM_001142935.2	NP_001136407.1	max dimerization protein 3 isoform b
NM_001394986.1	NP_001381915.1	max dimerization protein 3 isoform a
NM_001394987.1	NP_001381916.1	max dimerization protein 3 isoform c
NM_031300.4	NP_112590.1	max dimerization protein 3 isoform a

MXD3 Protein Structure

HLH

0
100
206 a.a.

Protein Preferred Names

Protein Names

max dimerization protein 3

Max-associated protein 3

Related Diseases

Diseases

Alias

Atrichia With Papular Lesions

Papular Atrichia	APL
Congenital Atrichia

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08862	MXD3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MXD3	VGNC	VGNC:55224
Macaca mulatta	MXD3	VGNC	VGNC:84451
Canis familiaris	MXD3	VGNC	VGNC:51904
Mus musculus	MXD3	MGD	MGI:104987
Rattus norvegicus	MXD3	RGD	RGD:628624