NUP88 - nucleoporin 88 Gene

Also Known as FADS4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4927

About NUP88

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,384,833-5,419,662 (from NCBI)

This gene has 33 transcripts (splice variants), 204 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 25.7), lymph node (RPKM 15.5) and 25 other tissues.

Summary

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

NUP88 Products (2)

mRNA Protein Name
NM_001320653.2 NP_001307582.1 nuclear pore complex protein Nup88 isoform 1
NM_002532.6 NP_002523.2 nuclear pore complex protein Nup88 isoform 2

NUP88 Protein Structure

Nup88

Nup88: Nuclear pore component (11 - 741)

  • 0
  • 200
  • 400
  • 600
  • 741 a.a.
Protein Preferred Names Protein Names

nuclear pore complex protein Nup88

  • karyoporin

NUP88 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUP88 Q99567 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
NUP88 Q99567 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
NUP88 Q99567 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
NUP88 Q99567 NUP214 Homo sapiens P35658
Anti Tag CoIP
33961781
Intra
NUP88 Q99567 NUP62 Homo sapiens P37198
Y2H Prey Pooling
32296183
Intra
NUP88 Q99567 NUP62 Homo sapiens P37198
Y2H Array
32296183
Intra
NUP88 Q99567 NUP62 Homo sapiens P37198
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fetal Akinesia Deformation Sequence 4

  • FADS4

  • Fetal Akinesia Deformation Sequence Syndrome 4

  • Akinesia, Fetal, Deformation Sequence, Type 4
Fetal Akinesia Deformation Sequence 1

  • Fetal Akinesia Deformation Sequence

  • Fads

  • Fetal Akinesia Sequence

  • FADS1

  • Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome Type 1

  • Fetal Akinesia Deformation Sequence Syndrome

  • Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

  • Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome, Type I

  • Foetal Akinesia Deformation Sequence Syndrome

  • Foetal Akinesia Sequence

  • Fetal Akinesia Deformation Sequence Syndrome 1

  • Pena-Shokeir Syndrome, Type 1

  • Pena Shokeir Syndrome, Type 1

  • Akinesia, Fetal, Deformation Sequence

  • Akinesia, Fetal, Deformation Sequence, Type 1

  • Pena-Shokeir Syndrome Type I
Cranioectodermal Dysplasia 4

  • CED4

  • Sensenbrenner Syndrome 4

  • Dysplasia, Cranioectodermal, Type 4
Anterior Horn Cell Disease
Lethal Congenital Contracture Syndrome 1

  • LCCS1

  • Multiple Contracture Syndrome, Finnish Type

  • Lccs

  • Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures

  • Lethal Congenital Contracture Syndrome Type 1

  • Herva Disease

  • Multiple Contracture Syndrome Finnish Type

  • Contracture Syndrome, Lethal, Congenital, Type 1
Lethal Congenital Contracture Syndrome

  • Lccs

  • Lethal Congenital Contracture Syndrome 1
Polyhydramnios
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09699 NUP88 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22698 Nup88 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29212 Nup88 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NUP88 VGNC VGNC:75562
Felis catus NUP88 VGNC VGNC:68600
Mus musculus NUP88 MGD MGI:104900
Canis familiaris NUP88 VGNC VGNC:44061
Rattus norvegicus NUP88 RGD RGD:620182
Bos taurus NUP88 VGNC VGNC:32365
Others NUP88 NCBI